Chicago White Sox vs Cleveland Guardians Preview: Odds, Spread, Time & TV (September 16, 2026)

The Chicago White Sox (77-74) visit the Cleveland Guardians (77-75) on Wednesday, September 16, 2026 at Progressive Field. First pitch is set for 1:10 PM ET. TV: ESPN; CHSN, Guardians.TV (regional).

Chicago White Sox vs Cleveland Guardians Odds & Preview Info

Matchup Chicago White Sox @ Cleveland Guardians
Records Chicago White Sox 77-74 | Cleveland Guardians 77-75
Run Line TBD
Moneyline Chicago White Sox: TBD | Cleveland Guardians: TBD
Total TBD
Venue Progressive Field
Date / Time Wednesday, September 16, 2026 — 1:10 PM ET
TV / How to Watch ESPN; CHSN, Guardians.TV (regional)
Probable Pitchers Chicago White Sox: Erick Fedde | Cleveland Guardians: Parker Messick

Odds TBD / not fully posted at research time via public sportsbooks (lines move — verify before betting).

Chicago White Sox Preview & Probable Pitcher

The Chicago White Sox enter Wednesday at 77-74 and travel to face the Cleveland Guardians at Progressive Field. Slated starter: Erick Fedde.

Track the run line, moneyline, and total listed above for this odds preview. Double-check probable pitchers and any late roster moves closer to first pitch at 1:10 PM ET.

Cleveland Guardians Preview & Probable Pitcher

The Cleveland Guardians sit at 77-75 hosting from Progressive Field. Probable starter: Parker Messick.

How to watch: ESPN; CHSN, Guardians.TV (regional). Odds and totals can shift through the evening — recheck your book for the latest Chicago White Sox vs Cleveland Guardians line before the September 16, 2026 first pitch.

Where to Watch Chicago White Sox vs Cleveland Guardians

Tune in Wednesday, September 16, 2026 at 1:10 PM ET from Progressive Field. Broadcast coverage: ESPN; CHSN, Guardians.TV (regional).