The San Francisco Giants (62-89) visit the St. Louis Cardinals (75-76) on Wednesday, September 16, 2026 at Busch Stadium. First pitch is set for 1:15 PM ET. TV: MLB.TV; NBC Sports BA, Cardinals.TV (regional).
San Francisco Giants vs St. Louis Cardinals Odds & Preview Info
| Matchup | San Francisco Giants @ St. Louis Cardinals |
|---|---|
| Records | San Francisco Giants 62-89 | St. Louis Cardinals 75-76 |
| Run Line | SF +1.5 | STL -1.5 |
| Moneyline | San Francisco Giants: +135 | St. Louis Cardinals: -164 |
| Total | 8.0 |
| Venue | Busch Stadium |
| Date / Time | Wednesday, September 16, 2026 — 1:15 PM ET |
| TV / How to Watch | MLB.TV; NBC Sports BA, Cardinals.TV (regional) |
| Probable Pitchers | San Francisco Giants: Anthony Molina | St. Louis Cardinals: Matthew Liberatore |
Odds shown via public sportsbooks (lines move — verify before betting).
San Francisco Giants Preview & Probable Pitcher
The San Francisco Giants enter Wednesday at 62-89 and travel to face the St. Louis Cardinals at Busch Stadium. Slated starter: Anthony Molina.
Track the run line, moneyline, and total listed above for this odds preview. Double-check probable pitchers and any late roster moves closer to first pitch at 1:15 PM ET.
St. Louis Cardinals Preview & Probable Pitcher
The St. Louis Cardinals sit at 75-76 hosting from Busch Stadium. Probable starter: Matthew Liberatore.
How to watch: MLB.TV; NBC Sports BA, Cardinals.TV (regional). Odds and totals can shift through the evening — recheck your book for the latest San Francisco Giants vs St. Louis Cardinals line before the September 16, 2026 first pitch.
Where to Watch San Francisco Giants vs St. Louis Cardinals
Tune in Wednesday, September 16, 2026 at 1:15 PM ET from Busch Stadium. Broadcast coverage: MLB.TV; NBC Sports BA, Cardinals.TV (regional).