Our Chargers vs Seahawks preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 4 matchup between the Los Angeles Chargers (0-3) and the Seattle Seahawks (2-1) on Sunday, October 4, 2026, at Lumen Field in Seattle, WA. Kickoff is 4:25 PM ET (1:25 PM PT), and the game airs on CBS.
Week 4 storyline: The winless Chargers visit the defending Super Bowl champion Seahawks, whose 12-game winning streak ended in Washington. Los Angeles is 0-3 for the first time since 2017, Jim Harbaugh publicly told Justin Herbert to “be better,” and offensive coordinator Mike McDaniel took the blame for the offense this week (ESPN). Seattle will be without both of its top running backs.
As of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET), DraftKings via ESPN lists the Seahawks as 7-point favorites over the Chargers, with the moneyline at Chargers +295 / Seahawks -375 and the over/under at 42.5. Since the open, the spread has moved from SEA -3 to SEA -7 and the total has moved from 45.5 to 42.5. Below are the full Chargers vs Seahawks odds, both team previews, the official Week 4 injury report and TV details.
Chargers vs Seahawks Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Los Angeles Chargers at Seattle Seahawks |
| Records | Chargers 0-3 (0-1 road) · Seahawks 2-1 (1-0 home) |
| Spread | Chargers +7 (-105) · Seahawks -7 (-115) |
| Moneyline | Chargers +295 · Seahawks -375 |
| Total | 42.5 (Over -118 / Under -102) |
| Venue | Lumen Field, Seattle, WA |
| Date/Time | Sunday, October 4, 2026 · 4:25 PM ET (1:25 PM PT) |
| TV | CBS |
| Head Coaches | Chargers: Jim Harbaugh · Seahawks: Mike Macdonald |
| Quarterbacks | Chargers: Justin Herbert · Seahawks: Sam Darnold |
Odds: DraftKings via ESPN as of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET). Opening line: SEA -3, total 45.5, moneyline Chargers +136 / Seahawks -162. Line movement: the spread has moved from SEA -3 to SEA -7, and the total has moved from 45.5 to 42.5; the moneyline has gone from Chargers +136 / Seahawks -162 at the open to Chargers +295 / Seahawks -375. The DraftKings line has unchanged since this preview first ran on Tuesday, Sept. 29. Lines can move before kickoff.
Los Angeles Chargers Preview
Season so far: The Chargers lost 26-14 at home to both Arizona and Las Vegas, then lost 24-16 at Buffalo in Week 3 despite forcing five turnovers. AP noted that through three games the offense has more punts (10) and turnovers (six) than touchdowns. Los Angeles has scored 44 points and allowed 76.
Quarterback and key players: Justin Herbert is 52 of 88 for 627 yards with three touchdowns and four interceptions (ESPN) in his first season with McDaniel. Omarion Hampton has 193 rushing yards and two touchdowns. Ladd McConkey leads the team with 183 receiving yards. Khalil Mack has two sacks, rookie S Genesis Smith had two interceptions in Buffalo, and Derwin James Jr. has 21 tackles.
This week: Harbaugh’s “be better” comment on Monday was a rare public critique of Herbert (ESPN). McConkey (foot) and James (hamstring, plus rest) were limited Friday and are questionable, and backup QB Trey Lance (groin) is also questionable.
Seattle Seahawks Preview
Season so far: Seattle beat New England 13-10 in the Super Bowl rematch after Sam Darnold was hurt on the opening drive, then won 31-7 at Arizona with its backup quarterback starting. In Week 3 the Seahawks lost 33-31 at Washington (AP). They have scored 75 points and allowed 50.
Quarterback and key players: Darnold returned in Week 3 and went 31 of 45 for 379 yards with four touchdowns and two interceptions (ESPN). Jaxon Smith-Njigba leads the NFL with 405 receiving yards and six touchdown catches; he and Jerry Rice (1989) are the only players with at least 120 receiving yards and a touchdown catch in each of their team’s first three games (AP). Leonard Williams has three sacks.
This week: Rookie RB Jadarian Price aggravated a chest injury in practice and was ruled out, and Macdonald said he is not sure how long Price will be sidelined (ESPN). Zach Charbonnet (ACL) is also out, leaving George Holani and the rest of the backfield. S Julian Love was a full participant Friday and is in line to return.
Chargers vs Seahawks Key Injuries
Source: the official final Week 4 injury reports released Friday, Oct. 2, as posted on NFL.com, with injured reserve moves from ESPN’s injury tracker and context from team sites and ESPN. Practice notes refer to Friday’s session. Players not listed below carry no game designation.
Los Angeles Chargers — Out: G Kayode Awosika (fibula); TE Charlie Kolar (forearm); WR Brenen Thompson (quadriceps); DT Dalvin Tomlinson (hamstring) · Doubtful: none · Questionable: CB Donte Jackson (concussion, full Friday); S Derwin James (hamstring, rest day, limited Friday); QB Trey Lance (groin, limited Friday); WR Ladd McConkey (foot, limited Friday); S Elijah Molden (hamstring, limited Friday) · Injured reserve (ESPN): OT Trey Pipkins III (knee).
Seattle Seahawks — Out: RB Zach Charbonnet (knee); RB Jadarian Price (chest) · Doubtful: none · Questionable: S Ty Okada (hamstring, full Friday); LB Chazz Surratt (calf, limited Friday) · Injured reserve (ESPN): G Anthony Bradford (knee).
Context: Macdonald said Price first hurt his chest in Week 2 and aggravated it in practice Wednesday. S Julian Love (calf), who missed Week 3, was a full participant Friday and has no designation (ESPN). Derwin James’s questionable tag also reflects a rest day.
Chargers vs Seahawks Key Matchup Notes
- Smith-Njigba vs the Chargers secondary: The NFL’s leading receiver faces a Los Angeles defense with CBs Elijah Molden and Donte Jackson questionable.
- Seattle’s backfield: With Price and Charbonnet out, the Seahawks turn to their depth backs, including Holani, against a Chargers front missing Tomlinson.
- Ball security: Herbert has four interceptions, and Price had lost fumbles in back-to-back games before his injury.
- Seattle’s safety depth: Love’s return helps a group that had Okada and Nick Emmanwori banged up in September.
- Market snapshot: DraftKings opened SEA -3 with a 45.5 total and now shows SEA -7 and 42.5 (DraftKings via ESPN, as of 7:01 AM PT Saturday).
Kickoff, Venue & How to Watch Los Angeles Chargers vs Seattle Seahawks
- Date: Sunday, October 4, 2026
- Kickoff: 4:25 PM ET (1:25 PM PT)
- Venue: Lumen Field, Seattle, WA
- TV / Streaming: CBS (regional broadcast; check local listings). Streaming: Paramount+ carries the local CBS feed, NFL+ streams local games on phones and tablets, and out-of-market viewers can use NFL Sunday Ticket on YouTube / YouTube TV
Where to watch: the Los Angeles Chargers vs Seattle Seahawks game airs on CBS at 4:25 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it does not offer betting advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET) for the Chargers vs Seahawks game on October 4, 2026.