Our Broncos vs 49ers preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 4 matchup between the Denver Broncos (2-1) and the San Francisco 49ers (3-0) on Sunday, October 4, 2026, at Levi’s Stadium in Santa Clara, CA. Kickoff is 4:25 PM ET (1:25 PM PT), and the game airs on CBS.
Week 4 storyline: Denver has won two straight comeback games and travels to face unbeaten San Francisco. The 49ers keep winning despite a long injury list: Nick Bosa is out, and WR Mike Evans (ribs) is a game-time decision, per Kyle Shanahan (ESPN). Off the field, the NFL suspended 49ers owner Jed York six games and fined him $500,000 under the personal conduct policy on Friday.
As of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET), DraftKings via ESPN lists the 49ers as 3-point favorites over the Broncos, with the moneyline at Broncos +124 / 49ers -148 and the over/under at 47.5. Since the open, the spread has moved from SF -2.5 to SF -3 and the total has moved from 46.5 to 47.5. Below are the full Broncos vs 49ers odds, both team previews, the official Week 4 injury report and TV details.
Broncos vs 49ers Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Denver Broncos at San Francisco 49ers |
| Records | Broncos 2-1 (0-1 road) · 49ers 3-0 (2-0 home) |
| Spread | Broncos +3 (-120) · 49ers -3 (+100) |
| Moneyline | Broncos +124 · 49ers -148 |
| Total | 47.5 (Over -115 / Under -105) |
| Venue | Levi’s Stadium, Santa Clara, CA |
| Date/Time | Sunday, October 4, 2026 · 4:25 PM ET (1:25 PM PT) |
| TV | CBS |
| Head Coaches | Broncos: Sean Payton · 49ers: Kyle Shanahan |
| Quarterbacks | Broncos: Bo Nix · 49ers: Brock Purdy |
Odds: DraftKings via ESPN as of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET). Opening line: SF -2.5, total 46.5, moneyline Broncos +114 / 49ers -135. Line movement: the spread has moved from SF -2.5 to SF -3, and the total has moved from 46.5 to 47.5; the moneyline has gone from Broncos +114 / 49ers -135 at the open to Broncos +124 / 49ers -148. The DraftKings line has moved from SF -3 (total 46.5) since this preview first ran on Tuesday, Sept. 29. Lines can move before kickoff.
Denver Broncos Preview
Season so far: Denver lost 31-10 at Kansas City, then came back to beat Jacksonville 20-13 and the Rams 30-26 in Week 3 after trailing 16-0 at halftime. Bo Nix’s go-ahead sneak came with 47 seconds left, and S Talanoa Hufanga had two interceptions, one returned 66 yards for a touchdown (AP). The Broncos have scored 60 points and allowed 70.
Quarterback and key players: Nix is 56 of 93 for 605 yards with four touchdowns and three interceptions (ESPN). J.K. Dobbins has 121 rushing yards. Jaylen Waddle, acquired from Miami in an offseason trade, leads the team with 150 receiving yards. Zach Allen has three sacks and Alex Singleton has 33 tackles.
This week: ESPN examined how the Broncos keep overcoming slow first halves with second-half rallies. WR Marvin Mims Jr., listed as out earlier, was a full participant Friday, along with Waddle, Dobbins and Allen. LB Dondrea Tillman (hamstring) is Denver’s only player ruled out on the final report.
San Francisco 49ers Preview
Season so far: San Francisco beat the Rams 27-7 in Melbourne, beat Miami 35-13 after scoring touchdowns on its first five drives, and beat Arizona 36-30 in Week 3. It is the 49ers’ third 3-0 start in four seasons (AP). They have scored 98 points and allowed 50.
Quarterback and key players: Brock Purdy is 60 of 83 for 789 yards with nine touchdowns and one interception (ESPN). AP says he leads the league with a 133.1 passer rating and has 10 total touchdowns. Christian McCaffrey has 166 rushing yards and three touchdowns, and George Kittle, back from a torn Achilles, has 174 receiving yards and three touchdowns. Fred Warner has 33 tackles and Keion White has two sacks.
This week: Evans was limited Friday after missing Wednesday and Thursday and said he will give “my best” to play (ESPN). LT Trent Williams, who left Week 3 with a stinger, practiced fully and has no designation. WR Christian Kirk (calf) went on injured reserve.
Broncos vs 49ers Key Injuries
Source: the official final Week 4 injury reports released Friday, Oct. 2, as posted on NFL.com, with injured reserve moves from ESPN’s injury tracker and context from team sites and ESPN. Practice notes refer to Friday’s session. Players not listed below carry no game designation.
Denver Broncos — Out: LB Dondrea Tillman (hamstring) · Doubtful: none · Questionable: none · Injured reserve (ESPN): RB Jonah Coleman (ankle).
San Francisco 49ers — Out: DE Nick Bosa (knee, calf); DT James Thompson Jr. (ankle); DE Mykel Williams (knee) · Doubtful: none · Questionable: LB Jaden Dugger (shoulder, limited Friday); WR Mike Evans (ribs, limited Friday); LB Dre Greenlaw (quadriceps, limited Friday); DE Keion White (hamstring, limited Friday) · Injured reserve (ESPN): WR Christian Kirk (calf).
Context: Bosa (knee, calf), DT James Thompson Jr. (ankle) and DE Mykel Williams (knee) are out. White (hamstring), LB Dre Greenlaw (quadriceps) and LB Jaden Dugger (shoulder) are questionable, which leaves San Francisco’s front seven thin against Denver.
Broncos vs 49ers Key Matchup Notes
- Purdy vs Hufanga and the Denver secondary: The league’s top-rated passer faces a defense that got two interceptions from Hufanga in Week 3.
- 49ers pass rush without Bosa: San Francisco has to pressure Nix without its top pass rusher, and White is questionable.
- Receiver depth: Evans is a game-time decision and Kirk is on IR, which could mean more targets for Kittle and McCaffrey.
- Second halves: Denver trailed at halftime in both of its comeback wins (ESPN).
- Market snapshot: DraftKings opened SF -2.5 with a 46.5 total and now shows SF -3 and 47.5 (DraftKings via ESPN, as of 7:01 AM PT Saturday).
Kickoff, Venue & How to Watch Denver Broncos vs San Francisco 49ers
- Date: Sunday, October 4, 2026
- Kickoff: 4:25 PM ET (1:25 PM PT)
- Venue: Levi’s Stadium, Santa Clara, CA
- TV / Streaming: CBS (regional broadcast; check local listings). Streaming: Paramount+ carries the local CBS feed, NFL+ streams local games on phones and tablets, and out-of-market viewers can use NFL Sunday Ticket on YouTube / YouTube TV
Where to watch: the Denver Broncos vs San Francisco 49ers game airs on CBS at 4:25 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it does not offer betting advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET) for the Broncos vs 49ers game on October 4, 2026.