Our Chargers vs Chiefs preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 6 matchup between the Los Angeles Chargers (0-5) and the Kansas City Chiefs (4-0) on Sunday, October 18, 2026, at Arrowhead Stadium in Kansas City, MO. Kickoff is 4:25 PM ET (1:25 PM PT), and the game airs on CBS.
Week 6 storyline: Unbeaten Kansas City comes off its bye to host the winless Chargers. Los Angeles is 0-5 for the first time since 2003, and Jim Harbaugh said he and ownership are in this fight together after a 23-17 loss to Denver he blamed on his own fourth-down call (ESPN).
As of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), DraftKings via ESPN lists the Chiefs as 8.5-point favorites over the Chargers, with the moneyline at Chargers +340 / Chiefs -440 and the over/under at 42.5. Since the open, the spread has moved from KC -2.5 to KC -8.5 and the total has moved from 46.5 to 42.5. Below are the full Chargers vs Chiefs odds, both team previews, the latest Week 6 injury news and TV details.
Chargers vs Chiefs Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Los Angeles Chargers at Kansas City Chiefs |
| Records | Chargers 0-5 (0-2 road) · Chiefs 4-0 (2-0 home) |
| Spread | Chargers +8.5 (-115) · Chiefs -8.5 (-105) |
| Moneyline | Chargers +340 · Chiefs -440 |
| Total | 42.5 (Over -108 / Under -112) |
| Venue | Arrowhead Stadium, Kansas City, MO |
| Date/Time | Sunday, October 18, 2026 · 4:25 PM ET (1:25 PM PT) |
| TV | CBS |
| Head Coaches | Chargers: Jim Harbaugh · Chiefs: Andy Reid |
| Starting QBs | Chargers: Justin Herbert · Chiefs: Patrick Mahomes |
Odds: DraftKings via ESPN as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET). Opening line: KC -2.5, total 46.5, moneyline Chargers +114 / Chiefs -135. Line movement: the spread has moved from KC -2.5 to KC -8.5, the total has moved from 46.5 to 42.5, and the moneyline has gone from Chargers +114 / Chiefs -135 at the open to Chargers +340 / Chiefs -440. Spread and total prices are shown in parentheses. Lines can move before kickoff.
Los Angeles Chargers Preview
2026 results through Week 6: Week 1: vs Cardinals, L 14-26 · Week 2: vs Raiders, L 14-26 · Week 3: at Bills, L 16-24 · Week 4: at Seahawks, L 23-30 · Week 5: vs Broncos, L 17-23. Points: 84 scored, 129 allowed.
Season so far: The Chargers lost 26-14 to Arizona and 26-14 to Las Vegas at home, 24-16 at Buffalo, 30-23 at Seattle and 23-17 to Denver. They have scored 84 points and allowed 129.
Quarterback and key players: Justin Herbert is 85 of 143 for 937 yards with five touchdowns and seven interceptions. Omarion Hampton has 271 rushing yards and three touchdowns, Tre’ Harris has 225 receiving yards, Khalil Mack has three sacks and Daiyan Henley has 32 tackles (ESPN).
This week: LT Rashawn Slater is on injured reserve after ankle surgery. WRs Quentin Johnston (chest) and Brenen Thompson (quadriceps), CB Donte Jackson and S Derwin James Jr. (hamstrings) are listed out, and Harris (hamstring) is doubtful.
Kansas City Chiefs Preview
2026 results through Week 6: Week 1: vs Broncos, W 31-10 · Week 2: vs Colts, W 33-30 · Week 3: at Dolphins, W 24-10 · Week 4: at Raiders, W 30-27. Points: 118 scored, 77 allowed.
Season so far: Kansas City beat Denver 31-10 and Indianapolis 33-30 at home, then won 24-10 at Miami and 30-27 at Las Vegas before a Week 5 bye. The Chiefs are one of two unbeaten teams, with San Francisco.
Quarterback and key players: Patrick Mahomes is 82 of 128 for 1,037 yards with nine touchdowns and two interceptions. Kenneth Walker III has 537 rushing yards and four touchdowns, Travis Kelce has 246 receiving yards and Nick Bolton has 37 tackles (ESPN).
This week: WR Tyquan Thornton went on injured reserve after ankle surgery. WR Rashee Rice (hamstring) and OT Josh Simmons (back) were listed questionable on ESPN’s tracker before the bye.
Chargers vs Chiefs Key Injuries
Source: ESPN’s injury tracker as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), with team-site, ESPN and NFL Network reporting for context. These are tracker statuses after Week 6, not official game designations: official Week 6 reports for this game run Wednesday through Friday, with game designations on Friday, Oct. 16. Some players listed questionable left Week 6 games and have not been updated yet.
Los Angeles Chargers — Out: WR Brenen Thompson (quadriceps); WR Quentin Johnston (chest); CB Donte Jackson (hamstring); S Derwin James Jr. (hamstring); OT Joe Alt (neck); G Kayode Awosika (lower leg); CB Rodney Shelley (hamstring) · Doubtful: WR Tre’ Harris (hamstring) · Questionable: WR Ladd McConkey (foot); LB Bud Dupree (neck) · Recent injured reserve moves (ESPN): G Trevor Penning (concussion); QB Trey Lance (groin); OT Rashawn Slater (ankle sprain).
Kansas City Chiefs — Out: none · Doubtful: none · Questionable: OT Josh Simmons (back); WR Rashee Rice (hamstring) · Recent injured reserve moves (ESPN): WR Tyquan Thornton (ankle surgery).
Rest note: Kansas City had a Week 5 bye; the Chargers played at home Sunday.
Chargers vs Chiefs Key Matchup Notes
- Division game: An AFC West game between the 4-0 Chiefs and 0-5 Chargers.
- Walker vs the Chargers’ defense: Walker has 537 rushing yards in four games.
- Herbert’s turnovers: Herbert has seven interceptions, and his receiving group is short-handed.
- Line movement: The spread opened at Chiefs -2.5; see the odds table for the current number.
- Market snapshot: DraftKings opened KC -2.5 with a 46.5 total and now shows KC -8.5 and 42.5 (DraftKings via ESPN, as of 1:59 AM PT Tuesday).
Kickoff, Venue & How to Watch Los Angeles Chargers vs Kansas City Chiefs
- Date: Sunday, October 18, 2026
- Kickoff: 4:25 PM ET (1:25 PM PT)
- Venue: Arrowhead Stadium, Kansas City, MO
- TV / Streaming: CBS (regional broadcast; check local listings). Streaming: Paramount+ carries the local CBS feed, NFL+ streams local games on phones and tablets, and out-of-market viewers can use NFL Sunday Ticket on YouTube / YouTube TV
Where to watch: the Los Angeles Chargers vs Kansas City Chiefs game airs on CBS at 4:25 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it is not gambling advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET) for the Chargers vs Chiefs game on October 18, 2026.