Our Bills vs Raiders preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 6 matchup between the Buffalo Bills (4-1) and the Las Vegas Raiders (3-2) on Sunday, October 18, 2026, at Allegiant Stadium in Las Vegas, NV. Kickoff is 4:25 PM ET (1:25 PM PT), and the game airs on CBS.
Week 6 storyline: Buffalo travels to Las Vegas on a short week after Josh Allen threw for 331 yards and won the first overtime game of his career, 37-34 at the Rams on Monday night. The Raiders lost 45-17 at New England, where No. 1 overall draft choice Fernando Mendoza made his NFL debut late in the fourth quarter (ESPN, AP).
As of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), DraftKings via ESPN lists the Bills as 6-point favorites over the Raiders, with the moneyline at Bills -285 / Raiders +230 and the over/under at 53.5. Since the open, the spread has moved from BUF -6.5 to BUF -6 and the total has moved from 47.5 to 53.5. Below are the full Bills vs Raiders odds, both team previews, the latest Week 6 injury news and TV details.
Bills vs Raiders Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Buffalo Bills at Las Vegas Raiders |
| Records | Bills 4-1 (2-0 road) · Raiders 3-2 (1-1 home) |
| Spread | Bills -6 (-110) · Raiders +6 (-110) |
| Moneyline | Bills -285 · Raiders +230 |
| Total | 53.5 (Over -105 / Under -115) |
| Venue | Allegiant Stadium, Las Vegas, NV |
| Date/Time | Sunday, October 18, 2026 · 4:25 PM ET (1:25 PM PT) |
| TV | CBS |
| Head Coaches | Bills: Joe Brady · Raiders: Klint Kubiak |
| Starting QBs | Bills: Josh Allen · Raiders: Kirk Cousins |
Odds: DraftKings via ESPN as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET). Opening line: BUF -6.5, total 47.5, moneyline Bills -285 / Raiders +230. Line movement: the spread has moved from BUF -6.5 to BUF -6, the total has moved from 47.5 to 53.5, and the moneyline is unchanged. Spread and total prices are shown in parentheses. Lines can move before kickoff.
Buffalo Bills Preview
2026 results through Week 6: Week 1: at Texans, W 36-31 · Week 2: vs Lions, W 41-31 · Week 3: vs Chargers, W 24-16 · Week 4: vs Patriots, L 26-29 · Week 5: at Rams, W 37-34. Points: 164 scored, 141 allowed.
Season so far: Buffalo won 36-31 at Houston, beat Detroit 41-31 and the Chargers 24-16, lost 29-26 to New England and won at SoFi Stadium. The Bills are 2-0 on the road.
Quarterback and key players: Allen is 91 of 138 for 1,249 yards with seven touchdowns and four interceptions. James Cook III has 532 rushing yards and five touchdowns but lost a fumble in overtime Monday. Dalton Kincaid has 277 receiving yards and Greg Rousseau has six sacks (ESPN).
This week: WR Joshua Palmer (shoulder), DE Landon Jackson (knee) and CB Dee Alford (ankle) are listed out, and OT Spencer Brown (back) is questionable.
Las Vegas Raiders Preview
2026 results through Week 6: Week 1: vs Dolphins, W 27-13 · Week 2: at Chargers, W 26-14 · Week 3: at Saints, W 35-27 · Week 4: vs Chiefs, L 27-30 · Week 5: at Patriots, L 17-45. Points: 132 scored, 129 allowed.
Season so far: Las Vegas opened 3-0 with wins over Miami (27-13), at the Chargers (26-14) and at New Orleans (35-27), then lost 30-27 to Kansas City and 45-17 at New England.
Quarterback and key players: Kirk Cousins is 112 of 172 for 1,269 yards with 12 touchdowns and four interceptions. Ashton Jeanty has 291 rushing yards, Brock Bowers has 312 receiving yards, Malcolm Koonce has three sacks and Nakobe Dean has 44 tackles (ESPN).
This week: WR Jalen Nailor (concussion) and C Trey Zuhn III (knee) are listed out, WR Dont’e Thornton Jr. went on injured reserve, and DT Tonka Hemingway and DE Patrick Johnson are questionable with stingers.
Bills vs Raiders Key Injuries
Source: ESPN’s injury tracker as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), with team-site, ESPN and NFL Network reporting for context. These are tracker statuses after Week 6, not official game designations: official Week 6 reports for this game run Wednesday through Friday, with game designations on Friday, Oct. 16. Some players listed questionable left Week 6 games and have not been updated yet.
Buffalo Bills — Out: DE Landon Jackson (knee); CB Dee Alford (ankle); WR Joshua Palmer (shoulder); DT Ed Oliver (knee); WR DJ Moore (shoulder – AC joint sprain) · Doubtful: none · Questionable: OT Spencer Brown (back); CB Te’Cory Couch (hamstring) · Recent injured reserve moves (ESPN): none since Sept. 29.
Las Vegas Raiders — Out: WR Jalen Nailor (concussion); C Trey Zuhn III (knee) · Doubtful: none · Questionable: DT Tonka Hemingway (concussion); DE Patrick Johnson (neck) · Recent injured reserve moves (ESPN): WR Dont’e Thornton Jr. (hamstring).
QB note: Cousins started Week 5; Mendoza played only late in the blowout.
Bills vs Raiders Key Matchup Notes
- Short week: Buffalo played Monday night and travels west again.
- Cook vs the Las Vegas front: Cook has 532 rushing yards on 95 carries.
- Bowers vs the Buffalo defense: Bowers leads the Raiders with 312 receiving yards.
- Total: The total has risen from the open; see the odds table.
- Market snapshot: DraftKings opened BUF -6.5 with a 47.5 total and now shows BUF -6 and 53.5 (DraftKings via ESPN, as of 1:59 AM PT Tuesday).
Kickoff, Venue & How to Watch Buffalo Bills vs Las Vegas Raiders
- Date: Sunday, October 18, 2026
- Kickoff: 4:25 PM ET (1:25 PM PT)
- Venue: Allegiant Stadium, Las Vegas, NV
- TV / Streaming: CBS (regional broadcast; check local listings). Streaming: Paramount+ carries the local CBS feed, NFL+ streams local games on phones and tablets, and out-of-market viewers can use NFL Sunday Ticket on YouTube / YouTube TV
Where to watch: the Buffalo Bills vs Las Vegas Raiders game airs on CBS at 4:25 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it is not gambling advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET) for the Bills vs Raiders game on October 18, 2026.