Our Cardinals vs Rams preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 6 matchup between the Arizona Cardinals (1-4) and the Los Angeles Rams (2-3) on Sunday, October 18, 2026, at SoFi Stadium in Inglewood, CA. Kickoff is 4:05 PM ET (1:05 PM PT), and the game airs on FOX.
Week 6 storyline: The Rams return home after a 37-34 overtime loss to Buffalo on Monday night, when they missed one field goal and had another blocked; Sean McVay said the team will evaluate everything about the kicking unit. Arizona lost 45-21 to Detroit, traded WR Marvin Harrison Jr. to Houston, and Mike LaFleur said he does not plan to change playcallers (ESPN).
As of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), DraftKings via ESPN lists the Rams as 13.5-point favorites over the Cardinals, with the moneyline at Cardinals +600 / Rams -900 and the over/under at 52.5. Since the open, the spread is unchanged from the open at LAR -13.5 and the total has moved from 46.5 to 52.5. Below are the full Cardinals vs Rams odds, both team previews, the latest Week 6 injury news and TV details.
Cardinals vs Rams Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Arizona Cardinals at Los Angeles Rams |
| Records | Cardinals 1-4 (1-2 road) · Rams 2-3 (1-2 home) |
| Spread | Cardinals +13.5 (-115) · Rams -13.5 (-105) |
| Moneyline | Cardinals +600 · Rams -900 |
| Total | 52.5 (Over -105 / Under -115) |
| Venue | SoFi Stadium, Inglewood, CA |
| Date/Time | Sunday, October 18, 2026 · 4:05 PM ET (1:05 PM PT) |
| TV | FOX |
| Head Coaches | Cardinals: Mike LaFleur · Rams: Sean McVay |
| Starting QBs | Cardinals: Jacoby Brissett · Rams: Matthew Stafford |
Odds: DraftKings via ESPN as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET). Opening line: LAR -13.5, total 46.5, moneyline Cardinals +500 / Rams -700. Line movement: the spread is unchanged from the open at LAR -13.5, the total has moved from 46.5 to 52.5, and the moneyline has gone from Cardinals +500 / Rams -700 at the open to Cardinals +600 / Rams -900. Spread and total prices are shown in parentheses. Lines can move before kickoff.
Arizona Cardinals Preview
2026 results through Week 6: Week 1: at Chargers, W 26-14 · Week 2: vs Seahawks, L 7-31 · Week 3: at 49ers, L 30-36 · Week 4: at Giants, L 24-36 · Week 5: vs Lions, L 21-45. Points: 108 scored, 162 allowed.
Season so far: Arizona won 26-14 at the Chargers in Week 1, then lost 31-7 to Seattle, 36-30 at San Francisco, 36-24 at the Giants and 45-21 to Detroit. The Cardinals have allowed 162 points.
Quarterback and key players: Jacoby Brissett is 132 of 199 for 1,110 yards with nine touchdowns and five interceptions. TE Trey McBride leads the team with 42 catches, rookie RB Jeremiyah Love has 245 rushing yards, and Budda Baker has 2.5 sacks and 36 tackles (ESPN).
This week: Harrison is gone, OT Paris Johnson Jr. (biceps surgery), G Isaiah Adams and TE Hunter Long are on injured reserve, and S Andrew Wingard (knee bruise) is listed out.
Los Angeles Rams Preview
2026 results through Week 6: Week 1: vs 49ers (Melbourne), L 7-27 · Week 2: vs Giants, W 28-6 · Week 3: at Broncos, L 26-30 · Week 4: at Eagles, W 24-20 · Week 5: vs Bills, L 34-37. Points: 119 scored, 120 allowed.
Season so far: The Rams lost 27-7 to San Francisco, beat the Giants 28-6, lost 30-26 at Denver, won 24-20 at Philadelphia and lost to the Bills in overtime.
Quarterback and key players: Matthew Stafford is 139 of 216 for 1,572 yards with nine touchdowns and six interceptions. Davante Adams has 441 receiving yards and four touchdowns, Kyren Williams has 343 rushing yards, Byron Young has 3.5 sacks and Nate Landman has 42 tackles (ESPN).
This week: LT Alaric Jackson punched Bills OLB Bradley Chubb on the field after Monday’s game in a scene captured by ESPN’s cameras, so any league response is worth watching. The Rams have six days between the Monday game and this one.
Cardinals vs Rams Key Injuries
Source: ESPN’s injury tracker as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), with team-site, ESPN and NFL Network reporting for context. These are tracker statuses after Week 6, not official game designations: official Week 6 reports for this game run Wednesday through Friday, with game designations on Friday, Oct. 16. Some players listed questionable left Week 6 games and have not been updated yet.
Arizona Cardinals — Out: S Andrew Wingard (knee bruise) · Doubtful: none · Questionable: S Wydett Williams Jr. (concussion) · Recent injured reserve moves (ESPN): G Isaiah Adams (ankle); OT Paris Johnson Jr. (biceps surgery); TE Hunter Long (knee).
Los Angeles Rams — Out: none · Doubtful: none · Questionable: none · Recent injured reserve moves (ESPN): DE Myles Garrett (knee surgery); TE Terrance Ferguson (ankle sprain).
Cardinals vs Rams Key Matchup Notes
- Division game: An NFC West game; both teams are under .500.
- Arizona without Harrison: McBride (42 catches) is the top remaining target.
- Kicking: McVay’s comments put the Rams’ kicking unit under review after the Buffalo game.
- Total: The total has moved up from the open; see the odds table.
- Market snapshot: DraftKings opened LAR -13.5 with a 46.5 total and now shows LAR -13.5 and 52.5 (DraftKings via ESPN, as of 1:59 AM PT Tuesday).
Kickoff, Venue & How to Watch Arizona Cardinals vs Los Angeles Rams
- Date: Sunday, October 18, 2026
- Kickoff: 4:05 PM ET (1:05 PM PT)
- Venue: SoFi Stadium, Inglewood, CA
- TV / Streaming: FOX (regional broadcast; check local listings). Streaming: Fox One and the FOX Sports app (local FOX feed), NFL+ on phones and tablets, and NFL Sunday Ticket on YouTube / YouTube TV for out-of-market viewers
Where to watch: the Arizona Cardinals vs Los Angeles Rams game airs on FOX at 4:05 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it is not gambling advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET) for the Cardinals vs Rams game on October 18, 2026.