Our Lions vs Cardinals preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 5 matchup between the Detroit Lions (2-2) and the Arizona Cardinals (1-3) on Sunday, October 11, 2026, at State Farm Stadium in Glendale, AZ. Kickoff is 4:25 PM ET (1:25 PM PT), and the game airs on FOX.
Week 5 storyline: Detroit has alternated wins and losses and comes off a 32-26 Sunday night loss at Carolina in which Bryce Young threw for 329 yards; Dan Campbell declined to discuss any change at defensive coordinator afterward. Arizona is 1-3 under first-year coach Mike LaFleur and lost LT Paris Johnson Jr. for the season to a torn biceps in a 36-24 loss to the Giants (ESPN, AP).
As of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET), DraftKings via ESPN lists the Lions as 4.5-point favorites over the Cardinals, with the moneyline at Lions -225 / Cardinals +185 and the over/under at 54.5. Since the open, the spread has moved from DET -8.5 to DET -4.5 and the total has moved from 49.5 to 54.5. Below are the full Lions vs Cardinals odds, both team previews, the latest Week 5 injury news and TV details.
Lions vs Cardinals Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Detroit Lions at Arizona Cardinals |
| Records | Lions 2-2 (0-2 road) · Cardinals 1-3 (0-1 home) |
| Spread | Lions -4.5 (-105) · Cardinals +4.5 (-115) |
| Moneyline | Lions -225 · Cardinals +185 |
| Total | 54.5 (Over -110 / Under -110) |
| Venue | State Farm Stadium, Glendale, AZ |
| Date/Time | Sunday, October 11, 2026 · 4:25 PM ET (1:25 PM PT) |
| TV | FOX |
| Head Coaches | Lions: Dan Campbell · Cardinals: Mike LaFleur |
| Starting QBs | Lions: Jared Goff · Cardinals: Jacoby Brissett |
Odds: DraftKings via ESPN as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET). Opening line: DET -8.5, total 49.5, moneyline Lions -395 / Cardinals +310. Line movement: the spread has moved from DET -8.5 to DET -4.5, the total has moved from 49.5 to 54.5, and the moneyline has gone from Lions -395 / Cardinals +310 at the open to Lions -225 / Cardinals +185. Spread and total prices are shown in parentheses. Lines can move before kickoff.
Detroit Lions Preview
2026 results through Week 4: Week 1: vs Saints, W 31-30 · Week 2: at Bills, L 31-41 · Week 3: vs Jets, W 31-24 · Week 4: at Panthers, L 26-32. Points: 119 scored, 127 allowed.
Season so far: Detroit beat New Orleans 31-30 in overtime after Kellen Moore’s two-point try for the win, lost 41-31 at Buffalo, beat the Jets 31-24 on Jahmyr Gibbs’ third touchdown and lost 32-26 at Carolina. The Lions are 2-0 at home and 0-2 on the road (AP).
Quarterback and key players: Jared Goff is 109 of 161 for 1,214 yards with nine touchdowns and no interceptions (ESPN), including 412 yards at Carolina. Gibbs has 353 rushing yards and five touchdowns, Amon-Ra St. Brown has 31 catches for 303 yards and five scores, Aidan Hutchinson has 3.5 sacks and LB Jack Campbell has 33 tackles.
This week: Dan Campbell said Friday that S Brian Branch (Achilles) is close to returning; CB Rock Ya-Sin (hamstring) is doubtful and G Ben Bartch (foot) is listed out. C Cade Mays (wrist) is on injured reserve and targeting Week 7. The Lions and TE Sam LaPorta broke off contract talks, per NFL Network (ESPN, Detroit News, Free Press).
Arizona Cardinals Preview
2026 results through Week 4: Week 1: at Chargers, W 26-14 · Week 2: vs Seahawks, L 7-31 · Week 3: at 49ers, L 30-36 · Week 4: at Giants, L 24-36. Points: 87 scored, 117 allowed.
Season so far: Arizona opened with a 26-14 upset at the Chargers as the league’s biggest Week 1 underdog, then lost 31-7 to Seattle, 36-30 at San Francisco and 36-24 at the Giants. The Cardinals are 0-1 at State Farm Stadium (AP).
Quarterback and key players: Jacoby Brissett is 103 of 152 for 818 yards with six touchdowns and four interceptions (ESPN); three of those interceptions came last week. Rookie RB Jeremiyah Love has 223 rushing yards, Michael Wilson leads with 25 catches for 258 yards, Budda Baker has 1.5 sacks and LB Jack Gibbens has 32 tackles.
This week: Johnson’s season-ending biceps tear leaves a hole at left tackle. Mike LaFleur said Love’s ankle issue is not related to the high-ankle sprain he had in August; G Isaiah Adams (ankle) and S Andrew Wingard (knee bone bruise) are also questionable, and S Dadrion Taylor-Demerson (back) is listed out (ESPN, team site, Arizona Republic).
Lions vs Cardinals Key Injuries
Source: ESPN’s injury tracker as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET), with team-site, ESPN and NFL Network reporting for context. These are tracker statuses after Week 4, not official game designations: official Week 5 reports for this game run Wednesday through Friday, with game designations on Friday, Oct. 9. Some players listed questionable left Week 4 games and have not been updated yet.
Detroit Lions — Out: G Ben Bartch (foot); S Brian Branch (Achilles surgery) · Doubtful: CB Rock Ya-Sin (hamstring) · Questionable: none · Recent injured reserve moves (ESPN): C Cade Mays (wrist fracture); S Thomas Harper (ankle).
Arizona Cardinals — Out: OT Paris Johnson Jr. (biceps surgery); S Dadrion Taylor-Demerson (back) · Doubtful: none · Questionable: S Andrew Wingard (knee bruise); RB Jeremiyah Love (ankle); G Isaiah Adams (ankle); TE Hunter Long (knee) · Recent injured reserve moves (ESPN): none since Sept. 22.
Context: Detroit’s secondary is thin, with Branch working back, Ya-Sin doubtful and S Thomas Harper (ankle) on injured reserve. Separately, the NFL suspended line judge Jeff Seeman two games for appearing to swear at Cardinals TE Trey McBride in Week 4 (ESPN).
Lions vs Cardinals Key Matchup Notes
- Goff’s efficiency: Goff has nine touchdown passes and no interceptions, and Arizona has allowed 107 points in four games.
- Arizona’s left tackle: The Cardinals must replace Johnson against a Detroit pass rush led by Hutchinson.
- Red-zone targets: Gibbs and St. Brown have five touchdowns each.
- Brissett’s turnovers: Brissett threw three interceptions against the Giants after throwing one in the first three games.
- Market snapshot: DraftKings opened DET -8.5 with a 49.5 total and now shows DET -4.5 and 54.5 (DraftKings via ESPN, as of 2:18 AM PT Tuesday).
Kickoff, Venue & How to Watch Detroit Lions vs Arizona Cardinals
- Date: Sunday, October 11, 2026
- Kickoff: 4:25 PM ET (1:25 PM PT)
- Venue: State Farm Stadium, Glendale, AZ
- TV / Streaming: FOX (regional broadcast; check local listings). Streaming: Fox One and the FOX Sports app (local FOX feed), NFL+ on phones and tablets, and NFL Sunday Ticket on YouTube / YouTube TV for out-of-market viewers
Where to watch: the Detroit Lions vs Arizona Cardinals game airs on FOX at 4:25 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it is not gambling advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET) for the Lions vs Cardinals game on October 11, 2026.