Our 49ers vs Seahawks preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 5 matchup between the San Francisco 49ers (4-0) and the Seattle Seahawks (3-1) on Sunday, October 11, 2026, at Lumen Field in Seattle, WA. Kickoff is 4:25 PM ET (1:25 PM PT), and the game airs on FOX.
Week 5 storyline: The 4-0 49ers visit the defending Super Bowl champion Seahawks in an NFC West game at Lumen Field. San Francisco keeps winning despite a growing injury list and is not projected to have DE Nick Bosa (calf) for this game, while Seattle is 3-1 after a 30-23 win over the Chargers in which it set a club record with 150 penalty yards (ESPN, AP).
As of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET), DraftKings via ESPN lists the Seahawks as 2.5-point favorites over the 49ers, with the moneyline at 49ers +124 / Seahawks -148 and the over/under at 47.5. Since the open, the spread has moved from SEA -3.5 to SEA -2.5 and the total has moved from 46.5 to 47.5. Below are the full 49ers vs Seahawks odds, both team previews, the latest Week 5 injury news and TV details.
49ers vs Seahawks Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | San Francisco 49ers at Seattle Seahawks |
| Records | 49ers 4-0 (1-0 road) · Seahawks 3-1 (2-0 home) |
| Spread | 49ers +2.5 (+100) · Seahawks -2.5 (-120) |
| Moneyline | 49ers +124 · Seahawks -148 |
| Total | 47.5 (Over -105 / Under -115) |
| Venue | Lumen Field, Seattle, WA |
| Date/Time | Sunday, October 11, 2026 · 4:25 PM ET (1:25 PM PT) |
| TV | FOX |
| Head Coaches | 49ers: Kyle Shanahan · Seahawks: Mike Macdonald |
| Starting QBs | 49ers: Brock Purdy · Seahawks: Sam Darnold |
Odds: DraftKings via ESPN as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET). Opening line: SEA -3.5, total 46.5, moneyline 49ers +164 / Seahawks -198. Line movement: the spread has moved from SEA -3.5 to SEA -2.5, the total has moved from 46.5 to 47.5, and the moneyline has gone from 49ers +164 / Seahawks -198 at the open to 49ers +124 / Seahawks -148. Spread and total prices are shown in parentheses. Lines can move before kickoff.
San Francisco 49ers Preview
2026 results through Week 4: Week 1: at Rams (Melbourne), W 27-7 · Week 2: vs Dolphins, W 35-13 · Week 3: vs Cardinals, W 36-30 · Week 4: vs Broncos, W 24-14. Points: 122 scored, 64 allowed.
Season so far: San Francisco beat the Rams 27-7 in Melbourne in the NFL’s first regular-season game in Australia, scored touchdowns on its first five drives in a 35-13 win over Miami, beat Arizona 36-30 behind four Brock Purdy touchdown passes and handled Denver 24-14 last week (AP).
Quarterback and key players: Purdy is 79 of 113 for 1,007 yards with 11 touchdowns and one interception (ESPN). Christian McCaffrey has 218 rushing yards and four touchdowns, George Kittle has 16 catches for 244 yards and four scores, Keion White has two sacks and LB Fred Warner leads with 40 tackles.
This week: FB Kyle Juszczyk (knee sprain) is set to miss two to three weeks, S Marques Sigle has a high ankle injury, and DT James Thompson Jr. (ankle) is not projected back for Week 5, per Kyle Shanahan. WR Christian Kirk (calf) is on injured reserve. Separately, the NFL suspended owner Jed York six games under the personal conduct policy (ESPN, The Athletic, Mercury News).
Seattle Seahawks Preview
2026 results through Week 4: Week 1: vs Patriots, W 13-10 · Week 2: at Cardinals, W 31-7 · Week 3: at Commanders, L 31-33 · Week 4: vs Chargers, W 30-23. Points: 105 scored, 73 allowed.
Season so far: Seattle beat New England 13-10 in a Super Bowl rematch, won 31-7 at Arizona, had its 12-game winning streak ended in a 33-31 loss at Washington and beat the Chargers 30-23, with Emanuel Wilson running for 81 yards and a touchdown (AP).
Quarterback and key players: Sam Darnold is 45 of 69 for 560 yards with six touchdowns and three interceptions (ESPN). Jaxon Smith-Njigba leads the NFL in receiving yards and touchdowns with 32 catches for 481 yards and six scores. Wilson has 190 rushing yards, Leonard Williams has three sacks and LB Ernest Jones IV leads with 41 tackles.
This week: RB Jadarian Price (chest) went on injured reserve, Zach Charbonnet (knee) will not come off the PUP list for this game, per Mike Macdonald, and sources told ESPN the Seahawks plan to sign veteran RB Joe Mixon to the practice squad. Macdonald said he anticipates DT Leonard Williams (ankle) being available. S Ty Okada (hamstring) and LB Chazz Surratt (calf) are listed out (ESPN, Seattle Times).
49ers vs Seahawks Key Injuries
Source: ESPN’s injury tracker as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET), with team-site, ESPN and NFL Network reporting for context. These are tracker statuses after Week 4, not official game designations: official Week 5 reports for this game run Wednesday through Friday, with game designations on Friday, Oct. 9. Some players listed questionable left Week 4 games and have not been updated yet.
San Francisco 49ers — Out: DT James Thompson Jr. (ankle sprain); DE Nick Bosa (calf strain) · Doubtful: S Marques Sigle (ankle); FB Kyle Juszczyk (knee sprain) · Questionable: none · Recent injured reserve moves (ESPN): WR Christian Kirk (calf).
Seattle Seahawks — Out: S Ty Okada (hamstring); LB Chazz Surratt (calf); RB Zach Charbonnet (knee – ACL surgery) · Doubtful: none · Questionable: DT Leonard Williams (ankle) · Recent injured reserve moves (ESPN): RB Jadarian Price (chest).
Context: San Francisco has played through injuries all season; WR Mike Evans (ribs) played in Week 4 after being listed as a game-time decision (ESPN).
49ers vs Seahawks Key Matchup Notes
- Purdy’s efficiency: Purdy has 11 touchdown passes and one interception, and the 49ers have scored 122 points.
- Smith-Njigba vs the 49ers secondary: Smith-Njigba has six touchdown catches, and San Francisco may be without Sigle.
- Pass rush without Bosa: San Francisco’s top sack total is two (White), and Seattle’s Williams has three.
- Penalties: Seattle had 150 penalty yards against the Chargers, a club record, and Macdonald called it unacceptable.
- Market snapshot: DraftKings opened SEA -3.5 with a 46.5 total and now shows SEA -2.5 and 47.5 (DraftKings via ESPN, as of 2:18 AM PT Tuesday).
Kickoff, Venue & How to Watch San Francisco 49ers vs Seattle Seahawks
- Date: Sunday, October 11, 2026
- Kickoff: 4:25 PM ET (1:25 PM PT)
- Venue: Lumen Field, Seattle, WA
- TV / Streaming: FOX (regional broadcast; check local listings). Streaming: Fox One and the FOX Sports app (local FOX feed), NFL+ on phones and tablets, and NFL Sunday Ticket on YouTube / YouTube TV for out-of-market viewers
Where to watch: the San Francisco 49ers vs Seattle Seahawks game airs on FOX at 4:25 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it is not gambling advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET) for the 49ers vs Seahawks game on October 11, 2026.