The San Francisco 49ers (6-0) and the Atlanta Falcons (2-4) meet at Mercedes-Benz Stadium on Sunday, October 25, with kickoff at 1:00 PM ET on FOX. The 49ers vs Falcons odds from DraftKings list San Francisco at -3.5 and a total of 49.5.
Season scoring: San Francisco 177-110, Atlanta 142-153. The table comes next, then form, statistics, injuries, line movement and broadcast details.
49ers vs Falcons Odds: Matchup Table
| Matchup | San Francisco 49ers at Atlanta Falcons |
| Records | 49ers 6-0 (2-0 road), Falcons 2-4 (0-3 home) |
| Spread | 49ers -3.5 (-115), Falcons +3.5 (-105) |
| Moneyline | 49ers -205, Falcons +170 |
| Total | 49.5 (Over -110, Under -110) |
| Venue | Mercedes-Benz Stadium, Atlanta, GA |
| Date | Sunday, October 25, 2026 |
| Kickoff | 1:00 PM ET |
| TV | FOX |
Snapshot of the 49ers vs Falcons odds at 5:19 AM ET on Tuesday, October 20, 2026 (DraftKings via ESPN); check for updates closer to the 1:00 PM ET start.
49ers Preview: Season Snapshot
Travel side of the 49ers vs Falcons odds: San Francisco. Six games in, San Francisco is 6-0 (2-0 on the road). Most recently, a 23-17 win against the Washington Commanders (at home) closed out Week 6 for San Francisco. It extended a streak of six wins for San Francisco. San Francisco owns a +67 point differential, built on 177 scored and 110 allowed.
San Francisco game by game:
- Week 1: W 27-7 at Los Angeles Rams
- Week 2: W 35-13 vs. Miami Dolphins
- Week 3: W 36-30 vs. Arizona Cardinals
- Week 4: W 24-14 vs. Denver Broncos
- Week 5: W 32-29 at Seattle Seahawks
- Week 6: W 23-17 vs. Washington Commanders
ESPN’s statistical leaders for San Francisco: Brock Purdy leads San Francisco in passing (119/171, 1,460 YDS, 14 TD, 2 INT). The rushing leader is Christian McCaffrey: 77 CAR, 350 YDS, 7 TD. In the receiving group, Mike Evans has 27 REC, 420 YDS, 3 TD. Defensively, Keion White has 3.5 sacks and Fred Warner leads with 58 tackles.
Scoring 29.5 points a game, San Francisco moves the ball for 371.5 yards per contest, 128.2 of them on runs. Efficiency: 8.5 yards per pass attempt, 4.6 per carry, 51.5% on third down and 85.0% touchdowns in the red zone.
Opponents score 18.3 points per game against San Francisco and gain 315.8 yards, 90.2 of it on the ground. San Francisco has 15 sacks, has allowed 5, and sits at +1 in turnover margin (7 takeaways, 6 giveaways). Field goals for San Francisco: 6-9.
Falcons Preview: 2-4 and at Home
Atlanta is the home side in the 49ers vs Falcons odds. Atlanta’s 2026 ledger shows 2-4 overall and 0-3 at home. In Week 6, Atlanta fell to the Chicago Bears 23-31 at home. Atlanta has now strung together two straight losses. Over six games Atlanta has scored 142 and allowed 153 (-11 differential).
Atlanta game by game:
- Week 1: L 13-20 at Pittsburgh Steelers
- Week 2: L 3-34 vs. Carolina Panthers
- Week 3: W 35-14 at Green Bay Packers
- Week 4: W 45-24 at New Orleans Saints
- Week 5: L 23-30 vs. Baltimore Ravens
- Week 6: L 23-31 vs. Chicago Bears
Atlanta averages 23.7 points and 360.5 yards per game, split between 211.0 passing and 149.5 rushing. A 38.9% third-down rate and a 75.0% red-zone touchdown rate go with 7.6 yards per attempt and 5.1 per carry for Atlanta.
ESPN’s statistical leaders for Atlanta: Michael Penix Jr. leads Atlanta in passing (71/110, 944 YDS, 6 TD, 1 INT). The rushing leader is Bijan Robinson: 111 CAR, 641 YDS, 4 TD. Drake London paces the pass catchers with 31 REC, 550 YDS. The sack leader is Za’Darius Smith (3.5); Xavier Watts leads in tackles (38).
Opponents score 25.5 points per game against Atlanta and gain 351.8 yards, 83.2 of it on the ground. Atlanta quarterbacks have taken 16 sacks, the defense has recorded 15, and the turnover ledger is -7. Field goals for Atlanta: 9-12.
49ers vs Falcons Odds: Injury Report
Here is where the San Francisco and Atlanta rosters stand on ESPN’s injury report as of 2026-10-20 09:19 UTC. Changes here are a common reason the 49ers vs Falcons odds shift during the week.
49ers Injury Report
- Out: LB Garret Wallow (hamstring strain); QB Kurtis Rourke (coach’s decision); WR Deebo Samuel Sr. (hamstring); S Marques Sigle (ankle); DT Naquan Jones (coach’s decision); DE Nick Bosa (calf strain); OT Enrique Cruz Jr. (coach’s decision)
- Doubtful: WR Mike Evans (achilles soreness)
- Questionable: LB Luke Gifford (groin)
- Injured reserve (most recent): WR Christian Kirk (calf)
Falcons Injury Report
- Out: CB C.J. Henderson (groin)
- Questionable: LB Kendal Daniels (neck); CB Billy Bowman Jr. (hamstring); LB Divine Deablo (arm)
49ers vs Falcons: Unit vs Unit
San Francisco’s 243.3 passing yards per game run into the Atlanta pass defense allowing 268.7; on the ground it is 128.2 gained against 83.2 conceded. Points: 29.5 scored per game by San Francisco, 25.5 allowed by Atlanta.
The other way, Atlanta scores 23.7 per game against the San Francisco defense allowing 18.3. Pass rush: 15 sacks for San Francisco, 15 for Atlanta. Those numbers are part of the backdrop for the 49ers vs Falcons odds.
49ers vs Falcons Odds: Key Trends
- Totals: 2 of 49ers games (6) and 3 of Falcons games (6) finished above 49.5 combined points.
- Splits: 49ers 2-0 on the road; Falcons 0-3 at home.
- Turnover margin: 49ers +1, Falcons -7.
- Third down: 49ers 51.5%, Falcons 38.9%.
- Red zone TD rate: 49ers 85.0%, Falcons 75.0%.
Use these season numbers to read the 49ers vs Falcons odds; they describe San Francisco and Atlanta through six weeks and nothing more.
The season scoring averages (San Francisco 29.5 for, 18.3 against; Atlanta 23.7 for, 25.5 against) sit well apart, which is part of the backdrop for the 49.5 total.
49ers vs Falcons Odds: Opening vs Current Line
From the first DraftKings posting to 5:19 AM ET Tuesday, the spread shifted from San Francisco -4.5 to San Francisco -3.5 and the total went from 47.5 at the open to 49.5. On the moneyline, Atlanta went +180 to +170 and San Francisco -218 to -205 in the 49ers vs Falcons odds.
Treat the 49.5 total and the -3.5 spread on San Francisco as a snapshot from 5:19 AM ET on Tuesday, October 20, 2026, not a final price.
49ers vs Falcons: TV, Time & Venue
- Date: Sunday, October 25, 2026
- Kickoff: 1:00 PM ET
- Venue: Mercedes-Benz Stadium, Atlanta, GA
- TV: FOX (NFL.com listing)
FOX carries San Francisco at Atlanta at 1:00 PM ET. More details are on ESPN’s matchup page; inactive lists come out about 90 minutes before kickoff.
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For background, see last week’s San Francisco preview and last week’s Atlanta preview. The NFL category has the rest of the slate, the free content hub collects our free coverage, and the NFL odds guide explains how lines are priced.
Informational only: the Atlanta vs San Francisco numbers above come from ESPN, DraftKings and NFL.com and may change before kickoff. This is not gambling advice. Need help? Call 1-800-GAMBLER.
49ers vs Falcons Odds: Frequently Asked Questions
What are the 49ers vs Falcons odds?
The 49ers vs Falcons odds: spread San Francisco -3.5, total 49.5, moneyline San Francisco -205 / Atlanta +170, per DraftKings via ESPN at 5:19 AM ET Tuesday.
What time does 49ers vs Falcons kick off?
The game starts at 1:00 PM ET, Sunday, October 25, 2026, at Mercedes-Benz Stadium.
Which network has 49ers vs Falcons?
FOX has the broadcast.
Where is 49ers vs Falcons played?
San Francisco travels to Mercedes-Benz Stadium (Atlanta) for this one.