Our Commanders vs 49ers preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 6 matchup between the Washington Commanders (1-3-1) and the San Francisco 49ers (5-0) on Monday, October 19, 2026, at Levi’s Stadium in Santa Clara, CA. Kickoff is 8:15 PM ET (5:15 PM PT), and the game airs on ESPN and ABC.
Week 6 storyline: Monday Night Football closes Week 6 in Santa Clara with the unbeaten 49ers hosting Washington. San Francisco beat Seattle 32-29 behind Mike Evans’ seven catches for 113 yards, and Washington tied the Giants 27-27 in Jayden Daniels’ return after a botched final overtime play that Dan Quinn called his responsibility (ESPN).
As of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), DraftKings via ESPN lists the 49ers as 7.5-point favorites over the Commanders, with the moneyline at Commanders +320 / 49ers -410 and the over/under at 50.5. Since the open, the spread has moved from SF -5.5 to SF -7.5 and the total is unchanged at 50.5. Below are the full Commanders vs 49ers odds, both team previews, the latest Week 6 injury news and TV details.
Commanders vs 49ers Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Washington Commanders at San Francisco 49ers |
| Records | Commanders 1-3-1 (0-2 road) · 49ers 5-0 (3-0 home) |
| Spread | Commanders +7.5 (-112) · 49ers -7.5 (-108) |
| Moneyline | Commanders +320 · 49ers -410 |
| Total | 50.5 (Over -118 / Under -102) |
| Venue | Levi’s Stadium, Santa Clara, CA |
| Date/Time | Monday, October 19, 2026 · 8:15 PM ET (5:15 PM PT) |
| TV | ESPN and ABC |
| Head Coaches | Commanders: Dan Quinn · 49ers: Kyle Shanahan |
| Starting QBs | Commanders: Jayden Daniels · 49ers: Brock Purdy |
Odds: DraftKings via ESPN as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET). Opening line: SF -5.5, total 50.5, moneyline Commanders +205 / 49ers -250. Line movement: the spread has moved from SF -5.5 to SF -7.5, the total is unchanged at 50.5, and the moneyline has gone from Commanders +205 / 49ers -250 at the open to Commanders +320 / 49ers -410. Spread and total prices are shown in parentheses. Lines can move before kickoff.
Washington Commanders Preview
2026 results through Week 6: Week 1: at Eagles, L 22-24 · Week 2: at Cowboys, L 20-37 · Week 3: vs Seahawks, W 33-31 · Week 4: vs Colts (London), L 13-30 · Week 5: vs Giants, T 27-27. Points: 115 scored, 149 allowed.
Season so far: Washington lost 24-22 at Philadelphia and 37-20 at Dallas, beat Seattle 33-31, lost 30-13 to Indianapolis and tied the Giants. The Commanders are 1-3-1 and 0-2 on the road.
Quarterback and key players: Daniels is 46 of 76 for 459 yards with three touchdowns and scored twice against the Giants. Jacory Croskey-Merritt has 239 rushing yards, Terry McLaurin has 203 receiving yards, K’Lavon Chaisson has 2.5 sacks and Jeremy Reaves has 37 tackles (ESPN).
This week: QB Marcus Mariota (MCL sprain), WR Stefon Diggs (hamstring), DE Charles Omenihu (groin) and S Tyler Owens and Nick Cross are listed out. ESPN noted the Washington defense has repeatedly faded in second halves.
San Francisco 49ers Preview
2026 results through Week 6: Week 1: at Rams (Melbourne), W 27-7 · Week 2: vs Dolphins, W 35-13 · Week 3: vs Cardinals, W 36-30 · Week 4: vs Broncos, W 24-14 · Week 5: at Seahawks, W 32-29. Points: 154 scored, 93 allowed.
Season so far: San Francisco won 27-7 at the Rams, beat Miami 35-13, Arizona 36-30 and Denver 24-14 at home, then won in Seattle. The 49ers are 5-0 and 3-0 in the NFC West.
Quarterback and key players: Brock Purdy is 98 of 142 for 1,196 yards with 13 touchdowns and two interceptions. Christian McCaffrey has 286 rushing yards and five touchdowns, Evans has 326 receiving yards, Keion White has three sacks and Fred Warner has 50 tackles (ESPN).
This week: LB Dre Greenlaw was suspended one game for a head-butt in Seattle, and DE Nick Bosa (calf) is listed out. WR Deebo Samuel will miss at least a couple of weeks with a hamstring injury, Kyle Shanahan said, and WR Christian Kirk and LB Nick Martin went on injured reserve.
Commanders vs 49ers Key Injuries
Source: ESPN’s injury tracker as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), with team-site, ESPN and NFL Network reporting for context. These are tracker statuses after Week 6, not official game designations: official Week 6 reports for this game run Thursday through Saturday, with game designations on Saturday, Oct. 17. Some players listed questionable left Week 6 games and have not been updated yet.
Washington Commanders — Out: DE Charles Omenihu (groin); S Tyler Owens (hamstring); QB Marcus Mariota (knee – MCL sprain); S Nick Cross (illness); WR Stefon Diggs (hamstring); S Percy Butler (hamstring) · Doubtful: none · Questionable: none · Recent injured reserve moves (ESPN): CB Trey Amos (ankle sprain); RB Jeremy McNichols (quadriceps); WR Jaylin Lane (ankle surgery).
San Francisco 49ers — Out: DT James Thompson Jr. (ankle sprain); FB Kyle Juszczyk (knee sprain); DE Nick Bosa (calf strain); LB Garret Wallow (hamstring strain); WR Deebo Samuel Sr. (hamstring); S Marques Sigle (ankle) · Doubtful: none · Questionable: none · Recent injured reserve moves (ESPN): LB Nick Martin (hamstring); WR Christian Kirk (calf).
Commanders vs 49ers Key Matchup Notes
- Daniels vs the San Francisco defense: The 49ers will be without Bosa and Greenlaw.
- Purdy’s efficiency: Purdy has 13 touchdown passes and two interceptions.
- Washington’s receivers: With Diggs out, McLaurin (203 yards) is the top healthy wideout.
- Line movement: The spread opened at 49ers -5.5; see the odds table for the current number.
- Market snapshot: DraftKings opened SF -5.5 with a 50.5 total and now shows SF -7.5 and 50.5 (DraftKings via ESPN, as of 1:59 AM PT Tuesday).
Kickoff, Venue & How to Watch Washington Commanders vs San Francisco 49ers
- Date: Monday, October 19, 2026
- Kickoff: 8:15 PM ET (5:15 PM PT)
- Venue: Levi’s Stadium, Santa Clara, CA
- TV / Streaming: ESPN and ABC (Monday Night Football; ESPN’s schedule lists both networks, while NFL.com lists ESPN). Streaming: the ESPN app with a qualifying subscription, plus NFL+ on phones and tablets
Where to watch: the Washington Commanders vs San Francisco 49ers game airs on ESPN and ABC at 8:15 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it is not gambling advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET) for the Commanders vs 49ers game on October 19, 2026.