Villanova faces No. 24 Louisville on Friday, September 11, 2026 at L&N Federal Credit Union Stadium, Louisville, KY. Kickoff is scheduled for 7:00 PM ET. The game airs on ACC Network. Below is a factual Week 2 college football matchup preview with current odds where available, including point spread, moneyline, over/under, venue, and broadcast information. Lines may move before kickoff.
Villanova vs Louisville odds and betting lines
| Matchup detail | Line / info |
|---|---|
| Records | Villanova — · Louisville — |
| Point spread | TBD — check public books closer to kickoff |
| Moneyline | TBD
How to watch Villanova vs Louisville
Villanova previewVillanova (—) visits Louisville on Friday, September 11, 2026. Villanova enters this matchup with 2026 staff listed on public directories where available. Early watch items include opening identity after Week 1, explosive-play balance, and matching the opponent's tempo in a ACC Network window. No. 24 Louisville previewNo. 24 Louisville (—) hosts at L&N Federal Credit Union Stadium. Louisville lists head coach Jeff Brohm, offensive coordinator Brian Brohm, and defensive coordinator Steve Ellis / Mark Ivey. Home-field framing, early-season continuity, and situational football are the factual focus points for this Week 2 preview. — check public books closer to kickoff |
| Over/under | TBD — check public books closer to kickoff |
| Location | L&N Federal Credit Union Stadium, Louisville, KY |
| Date | Friday, September 11, 2026 |
| Kickoff time | 7:00 PM ET |
| TV channel | ACC Network |
Odds: Public odds were not listed on ESPN/DraftKings at research time for every market. Lines may move before kickoff.