Minnesota Twins vs San Francisco Giants Preview: Odds, Spread, Time & TV (September 21, 2026)

The Minnesota Twins (73-83) visit the San Francisco Giants (64-92) on Monday, September 21, 2026 at Oracle Park. First pitch is set for 9:45 PM ET. TV: MLB.TV / Twins.TV / NBC Sports BA.

Minnesota Twins vs San Francisco Giants Odds & Preview Info

Matchup Minnesota Twins @ San Francisco Giants
Records Minnesota Twins 73-83 | San Francisco Giants 64-92
Run Line MIN -1.5 | SF +1.5
Moneyline Minnesota Twins: -117 | San Francisco Giants: -103
Total 8.0
Venue Oracle Park
Date / Time Monday, September 21, 2026 — 9:45 PM ET
TV / How to Watch MLB.TV / Twins.TV / NBC Sports BA
Probable Pitchers Minnesota Twins: Zebby Matthews (9-10, 4.74) | San Francisco Giants: Blade Tidwell (1-2, 4.56)

Odds shown via public sportsbooks (lines move — verify before betting).

Minnesota Twins Preview & Probable Pitcher

The Minnesota Twins enter Monday at 73-83 and travel to face the San Francisco Giants at Oracle Park. Slated starter: Zebby Matthews (9-10, 4.74).

Track the run line, moneyline, and total listed above for this odds preview. Double-check probable pitchers and any late roster moves closer to first pitch at 9:45 PM ET.

San Francisco Giants Preview & Probable Pitcher

The San Francisco Giants sit at 64-92 hosting from Oracle Park. Probable starter: Blade Tidwell (1-2, 4.56).

How to watch: MLB.TV / Twins.TV / NBC Sports BA. Odds and totals can shift through the afternoon and evening — recheck your book for the latest Minnesota Twins vs San Francisco Giants line before the September 21, 2026 first pitch.

Where to Watch Minnesota Twins vs San Francisco Giants

Tune in Monday, September 21, 2026 at 9:45 PM ET from Oracle Park. Broadcast coverage: MLB.TV / Twins.TV / NBC Sports BA.