No. 16 SMU faces No. 23 Louisville on Saturday, September 19, 2026 at L&N Federal Credit Union Stadium, Louisville, KY. Kickoff is scheduled for 3:30 PM ET. The game airs on ESPN2. Below is a factual Week 3 college football matchup preview with current odds where available, including point spread, moneyline, over/under, venue, and broadcast information. Lines may move before kickoff.
SMU vs Louisville odds and betting lines
| Matchup detail | Line / info |
|---|---|
| Records | SMU 2-0 · Louisville 1-1 |
| Point spread | LOU -1.5 |
| Moneyline | SMU +105 · Louisville -125 |
| Over/under | 59.5 |
| Location | L&N Federal Credit Union Stadium, Louisville, KY |
| Date | Saturday, September 19, 2026 |
| Kickoff time | 3:30 PM ET |
| TV channel | ESPN2 |
Odds: DraftKings lines reported via ESPN around research time. Lines may move before kickoff.
How to watch SMU vs Louisville
- Date: Saturday, September 19, 2026
- Time: 3:30 PM ET
- Venue: L&N Federal Credit Union Stadium, Louisville, KY
- TV: ESPN2
No. 16 SMU preview
No. 16 SMU (2-0) visits Louisville on Saturday, September 19, 2026. SMU lists head coach Rhett Lashlee. Early watch items include Week 3 identity, explosive-play balance, and matching the opponent's tempo in an ESPN2 window.
No. 23 Louisville preview
No. 23 Louisville (1-1) hosts at L&N Federal Credit Union Stadium. Louisville lists head coach Jeff Brohm. Home-field framing, early-season continuity, and situational football are the factual focus points for this Week 3 preview.