No. 20 Oregon (2-1) faces No. 12 USC (4-0) on Saturday, September 26, 2026 at Los Angeles Memorial Coliseum, Los Angeles, CA. Kickoff is scheduled for 7:30 PM ET. The game airs on NBC. Below is a factual Week 4 college football matchup preview with current odds where available — point spread, moneyline, over/under, venue, broadcast, and coaching staff. Lines may move before kickoff.
Oregon vs USC Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | No. 20 Oregon at No. 12 USC |
| Records | Oregon 2-1 · USC 4-0 |
| Spread | ORE -2.5 |
| Moneyline | Oregon -142 · USC +120 |
| Total | 62.5 |
| Venue | Los Angeles Memorial Coliseum, Los Angeles, CA |
| Date/Time | Saturday, September 26, 2026 · 7:30 PM ET |
| TV / How to Watch | NBC |
| Head Coaches | Oregon: HC Dan Lanning, OC Drew Mehringer · USC: HC Lincoln Riley, OC Luke Huard |
No. 20 Oregon Preview & Staff
No. 20 Oregon (2-1) visits USC on Saturday, September 26, 2026. Oregon lists head coach Dan Lanning and offensive coordinator Drew Mehringer. This Week 4 preview is informational only no free picks or predictions. Early watch items include Week 4 identity, explosive-play balance, and matching the opponent's tempo in a NBC window.
No. 12 USC Preview & Staff
No. 12 USC (4-0) hosts at Los Angeles Memorial Coliseum. USC lists head coach Lincoln Riley and offensive coordinator Luke Huard. Home-field framing, early-season continuity, and situational football are the factual focus points for this Week 4 matchup preview.
Where to Watch
- Date: Saturday, September 26, 2026
- Time: 7:30 PM ET
- Venue: Los Angeles Memorial Coliseum, Los Angeles, CA
- TV: NBC
Odds: DraftKings lines reported via ESPN around research time. Lines may move before kickoff. This page is a matchup preview only and does not include free picks or betting recommendations.