The No. 18 Oklahoma State Cowboys (4-1) visit the No. 20 Houston Cougars (5-1) on Saturday, October 17, 2026 at TDECU Stadium, Houston, TX. Kickoff is scheduled for 7:30 PM ET, and the game airs on FOX. DraftKings lists the spread at HOU -4.5 with a total of 61.5; moneylines are Oklahoma State +154 · Houston -185. Below is our Oklahoma State vs Houston preview with the latest odds, point spread, moneyline, over/under, kickoff time, TV channel and where to watch, plus a look at each team’s season so far, head coach and key players. Lines may move before kickoff.
Oklahoma State vs Houston Odds, Spread, Kickoff Time & TV
| Matchup detail | Line / info |
|---|---|
| Matchup | No. 18 Oklahoma State at No. 20 Houston |
| Records | Oklahoma State 4-1 · Houston 5-1 |
| Spread | HOU -4.5 |
| Moneyline | Oklahoma State +154 · Houston -185 |
| Total | 61.5 |
| Venue | TDECU Stadium, Houston, TX |
| Date/Time | Saturday, October 17, 2026 · 7:30 PM ET |
| TV / How to Watch | FOX |
| Head Coaches | Oklahoma State: HC Eric Morris, OC Sean Brophy · Houston: HC Willie Fritz, OC Slade Nagle |
Oklahoma State Preview: Season So Far, Coach & Key Players
Season so far: The Oklahoma State Cowboys are 4-1 overall, 2-0 in Big 12 play, and they are ranked No. 18 in this week’s AP Top 25. Results to date: Sep 5 — L 24-10 at Tulsa; Sep 12 — W 39-31 vs Oregon; Sep 19 — W 59-0 vs Murray State; Sep 26 — W 41-24 at West Virginia; Oct 10 — W 42-28 vs UCF. Most recently, Oklahoma State beat UCF 42-28 at home. Through 5 games, Oklahoma State is averaging 38.2 points scored and 21.4 points allowed per game.
Head coach: Eric Morris (first season in charge). Offensive coordinator: Sean Brophy. Defensive coordinator: Skyler Cassity.
Key players (2026 season stats):
- Passing leader: Drew Mestemaker (QB) — 114/169, 1,575 yards, 13 TD, 5 INT
- Rushing leader: Caleb Hawkins (RB) — 106 carries, 524 yards, 2 TD
- Receiving leader: Wyatt Young (WR) — 27 receptions, 462 yards, 4 TD
- Sacks leader: Jaleel Johnson (DE) — 1.5 sacks
- Tackles leader: Ethan Wesloski (LB) — 53 total tackles
Strengths: An offense scoring 38.2 points per game; Drew Mestemaker’s passing volume (1,575 yards); Caleb Hawkins’s production on the ground (524 rushing yards). Questions: Ball security at quarterback (5 interceptions for Drew Mestemaker).
Houston Preview: Season So Far, Coach & Key Players
Season so far: The Houston Cougars are 5-1 overall, 2-1 in Big 12 play, and they are ranked No. 20 in this week’s AP Top 25. Results to date: Sep 5 — W 33-20 vs Oregon State; Sep 12 — W 77-6 vs Southern; Sep 18 — L 28-26 at Texas Tech; Sep 26 — W 42-28 at Georgia Southern; Oct 3 — W 27-17 vs UCF; Oct 10 — W 35-16 at Kansas State. Most recently, Houston beat Kansas State 35-16 on the road. Through 6 games, Houston is averaging 40.0 points scored and 19.2 points allowed per game.
Head coach: Willie Fritz (head coach since 2024). Offensive coordinator: Slade Nagle. Defensive coordinator: Austin Armstrong.
Key players (2026 season stats):
- Passing leader: Conner Weigman (QB) — 110/165, 1,428 yards, 15 TD, 1 INT
- Rushing leader: Re'Shaun Sanford II (RB) — 75 carries, 404 yards, 2 TD
- Receiving leader: Patrick Overmyer (TE) — 33 receptions, 400 yards, 6 TD
- Sacks leader: Javion White (DB) — 2.5 sacks
- Tackles leader: Kentrell Webb (DB) — 38 total tackles
Strengths: An offense scoring 40.0 points per game; a defense holding opponents to 19.2 points per game. Questions: Holding serve at TDECU Stadium against Oklahoma State.
How to Watch Oklahoma State vs Houston
- Date: Saturday, October 17, 2026
- Kickoff: 7:30 PM ET
- Venue: TDECU Stadium, Houston, TX
- TV / Streaming: FOX
Odds: DraftKings lines reported via ESPN as of October 12, 2026 2:12 AM PT (Arizona time). Lines may move before kickoff. Records, results and season stats via ESPN; coaching staffs per 2026 staff listings. This page is an informational matchup preview only.