Mississippi State faces South Carolina on Saturday, September 19, 2026 at Williams-Brice Stadium, Columbia, SC. Kickoff is scheduled for 4:15 PM ET. The game airs on SEC Network. Below is a factual Week 3 college football matchup preview with current odds where available, including point spread, moneyline, over/under, venue, and broadcast information. Lines may move before kickoff.
Mississippi State vs South Carolina odds and betting lines
| Matchup detail | Line / info |
|---|---|
| Records | Mississippi State 2-0 · South Carolina 2-0 |
| Point spread | SC -3.5 |
| Moneyline | Mississippi State +142 · South Carolina -170 |
| Over/under | 58.5 |
| Location | Williams-Brice Stadium, Columbia, SC |
| Date | Saturday, September 19, 2026 |
| Kickoff time | 4:15 PM ET |
| TV channel | SEC Network |
Odds: DraftKings lines reported via ESPN around research time. Lines may move before kickoff.
How to watch Mississippi State vs South Carolina
- Date: Saturday, September 19, 2026
- Time: 4:15 PM ET
- Venue: Williams-Brice Stadium, Columbia, SC
- TV: SEC Network
Mississippi State preview
Mississippi State (2-0) visits South Carolina on Saturday, September 19, 2026. Mississippi State lists head coach Jeff Lebby. Early watch items include Week 3 identity, explosive-play balance, and matching the opponent’s tempo in an SEC Network window.
South Carolina preview
South Carolina (2-0) hosts at Williams-Brice Stadium. South Carolina lists head coach Shane Beamer. Home-field framing, early-season continuity, and situational football are the factual focus points for this Week 3 preview.