No. 24 Louisville faces No. 9 Ole Miss on Sunday, Sept. 6, 2026, at Nissan Stadium in Nashville in a Week 1 ACC–SEC showcase. Kickoff is 7:30 p.m. ET on ABC. Here is the matchup preview with current odds, point spread, moneyline, and total.
Louisville vs Ole Miss odds and betting lines
| Matchup detail | Line / info |
|---|---|
| Records | Louisville 0-0 · Ole Miss 0-0 |
| Point spread | Ole Miss -6.5 |
| Moneyline | Louisville +210 · Ole Miss -250 |
| Over/under | 55.5 |
| Location | Nissan Stadium · Nashville, TN |
| Date | Sunday, Sept. 6, 2026 |
| Kickoff time | 7:30 p.m. ET |
| TV channel | ABC |
Odds are public consensus-style lines and may move before kickoff.
How to watch Louisville vs Ole Miss
- TV: ABC
- Venue: Nissan Stadium, Nashville, Tennessee
No. 24 Louisville Cardinals preview
Louisville enters 2026 after a 9-4 finish in 2025. This neutral-site opener is an early measuring stick against a top-10 SEC opponent. Quarterback efficiency, explosive plays on the perimeter, and forcing long fields will shape how competitive the Cardinals look in this Week 1 preview.
No. 9 Ole Miss Rebels preview
Ole Miss opens Pete Golding’s first full season as head coach after he was promoted when Lane Kiffin left for LSU following the 2025 regular season. Golding then led the Rebels through a deep College Football Playoff run. Offensive coordinator John David Baker remains a key continuity piece. Red-zone finishing and matching Louisville’s athleticism are early watch items in Nashville.