The Miami Dolphins (0-1) face the San Francisco 49ers (1-0) on Sunday, September 20, 2026 at Levi’s Stadium, Santa Clara, CA. Kickoff is scheduled for 4:25 PM ET. The game airs on FOX. This NFL Week 2 regular-season matchup is listed with the kickoff and TV details below.
Below is a factual NFL Week 2 matchup preview with current odds information, including point spread, moneyline, over/under, venue, kickoff time, and TV. This is an informational odds and broadcast preview only — no projected winner or betting advice. Lines may move before kickoff.
Dolphins vs 49ers odds and betting lines
| Matchup detail | Line / info |
|---|---|
| Records | Dolphins 0-1 · 49ers 1-0 |
| Point spread | MIA +12.5 · SF -12.5 |
| Moneyline | MIA +600 · SF -900 |
| Over/under | 46.5 |
| Location | Levi’s Stadium, Santa Clara, CA |
| Date | Sunday, September 20, 2026 |
| Kickoff time | 4:25 PM ET |
| TV channel | FOX |
Odds shown via DraftKings@ESPN / public sportsbooks. Lines may move before kickoff — verify at your sportsbook. Some shops may show slight differences versus ESPN consensus.
How to watch Dolphins vs 49ers
- Date: Sunday, September 20, 2026
- Time: 4:25 PM ET
- Venue: Levi’s Stadium, Santa Clara, CA
- TV / where to watch: FOX
Miami Dolphins preview
The Miami Dolphins enter this Week 2 road matchup at 0-1 after Week 1. The Dolphins travel to face the 49ers at Levi’s Stadium with kickoff set for 4:25 PM ET on FOX. Public odds boards have the Dolphins listed at +600 on the moneyline against the posted SF -12.5 home-favorite line. The consensus total sits near 46.5. This page is an odds, spread, kickoff, and TV preview only — recheck lines and availability closer to Sunday, September 20, 2026.
San Francisco 49ers preview
The San Francisco 49ers host Week 2 action at Levi’s Stadium at 1-0 after Week 1. The 49ers are listed as home favorites on the SF -12.5 spread with a -900 moneyline. Broadcast coverage is on FOX at 4:25 PM ET. Use the table above for the latest listed spread, moneyline, and total, and confirm where to watch in your market before kickoff.
Dolphins vs 49ers kickoff and TV info
Mark your calendar for Sunday, September 20, 2026 at 4:25 PM ET. The Miami Dolphins vs San Francisco 49ers Week 2 game is scheduled from Levi’s Stadium, Santa Clara, CA and airs on FOX. Odds can shift through the week — refresh your book for the current point spread, moneyline, and over/under before the ball is kicked.