CBS has the call on Sunday, October 25 at 1:00 PM ET when the Indianapolis Colts (2-4) take on the Minnesota Vikings (5-0) at U.S. Bank Stadium. In the Colts vs Vikings odds, Minnesota is -6.5 with a 41.5 total.
Before the details, a scoring snapshot: Indianapolis 144 for and 164 against, Minnesota 109 for and 64 against.
Colts vs Vikings Odds & Game Info
| Matchup | Indianapolis Colts at Minnesota Vikings |
| Records | Colts 2-4 (1-2 road), Vikings 5-0 (2-0 home) |
| Spread | Vikings -6.5 (-108), Colts +6.5 (-112) |
| Moneyline | Colts +225, Vikings -278 |
| Total | 41.5 (Over -110, Under -110) |
| Venue | U.S. Bank Stadium, Minneapolis, MN |
| Date | Sunday, October 25, 2026 |
| Kickoff | 1:00 PM ET |
| TV | CBS |
Snapshot of the Colts vs Vikings odds at 5:19 AM ET on Tuesday, October 20, 2026 (DraftKings via ESPN); check for updates closer to the 1:00 PM ET start.
Colts Preview: Season Snapshot
For the visitors in the Colts vs Vikings odds, Indianapolis makes the trip to Minneapolis. Indianapolis sits at 2-4 through six games, 1-2 on the road. Indianapolis played the Tennessee Titans last, a 20-26 loss at home. Indianapolis has now strung together two straight losses. The scoreboard math for Indianapolis: 144 points for, 164 against, -20 net.
2026 results:
- Week 1: L 23-41 vs. Baltimore Ravens
- Week 2: L 30-33 at Kansas City Chiefs
- Week 3: W 19-17 vs. Houston Texans
- Week 4: W 30-13 at Washington Commanders
- Week 5: L 22-34 at Pittsburgh Steelers
- Week 6: L 20-26 vs. Tennessee Titans
Through the air Indianapolis gains 215.0 yards per game, on the ground 111.5, for 326.5 total and 24.0 points per game. Per play, Indianapolis gets 5.9 yards a pass and 4.0 a run; its third-down rate is 37.4% and its red-zone TD rate 63.2%.
ESPN’s statistical leaders for Indianapolis: Daniel Jones is Indianapolis’s passing leader at 130/218, 1,290 YDS, 4 TD, 6 INT. Jonathan Taylor is the top rusher (122 CAR, 492 YDS, 7 TD). Josh Downs leads the receivers (24 REC, 289 YDS). Defensively, DeForest Buckner has 4 sacks and Akeem Davis-Gaither leads with 53 tackles.
Defensively, Indianapolis allows 27.3 points and 362.8 yards per game (240.3 passing, 122.5 rushing). The Indianapolis pass rush owns 10 sacks while its quarterbacks have been dropped 15 times; turnover margin is -8. On field goals Indianapolis is 18-18.
Vikings Preview: Results & Team Stats
The other half of the Colts vs Vikings odds is Minnesota. Heading into Sunday, the Minnesota side owns a 5-0 record and is 2-0 at home. Minnesota played the New Orleans Saints last, a 23-13 win on the road. That is five wins in a row for Minnesota. The bye for Minnesota came in Week 6. Minnesota owns a +45 point differential, built on 109 scored and 64 allowed.
Minnesota game by game:
- Week 1: W 39-22 vs. Green Bay Packers
- Week 2: W 9-3 at Chicago Bears
- Week 3: W 23-16 at Tampa Bay Buccaneers
- Week 4: W 15-10 vs. Miami Dolphins
- Week 5: W 23-13 at New Orleans Saints
ESPN’s statistical leaders for Minnesota: Kyler Murray is Minnesota’s passing leader at 69/101, 662 YDS, 2 TD, 2 INT. Aaron Jones Sr. carries the rushing load (97 CAR, 410 YDS, 2 TD). Justin Jefferson paces the pass catchers with 19 REC, 258 YDS, 3 TD. Defensively, Dallas Turner has 5.5 sacks and Blake Cashman leads with 42 tackles.
On offense, the Minnesota Vikings put up 21.8 points and 303.6 yards per game, with 187.6 of those yards coming through the air. Inside the 20, Minnesota scores touchdowns 50.0% of the time, and it moves the chains on 38.0% of third downs (6.7 per pass, 3.8 per rush).
The Minnesota defense gives up 282.0 yards per game, 195.4 through the air, and 12.8 points. With 10 takeaways against 4 giveaways, Minnesota is +6 in turnovers, and it has 17 sacks. Field goals for Minnesota: 15-15.
Colts and Vikings Injury Report
Availability matters for the Colts vs Vikings odds. ESPN’s report (2026-10-20 09:19 UTC) shows the statuses below for Indianapolis and Minnesota; team practice reports arrive later in the week.
Colts Injury Report
- Out: TE Tyler Warren (groin); LB Jaylon Carlies (ribs); WR Ashton Dulin (hamstring)
- Doubtful: CB Sauce Gardner (calf strain)
- Questionable: P Rigoberto Sanchez (foot); WR Anthony Gould (concussion)
- Injured reserve (most recent): WR Alec Pierce (heel); DE Arden Key (hamstring)
Vikings Injury Report
- Questionable: OT Christian Darrisaw (concussion); CB Charles Demmings (hamstring); WR Jordan Addison (hamstring soreness); TE T.J. Hockenson (concussion)
- Injured reserve (most recent): RB Jordan Mason (thumb surgery); G Donovan Jackson (knee – meniscus surgery); TE Josh Oliver (biceps surgery)
Colts vs Vikings Odds: Season Trends
- Totals: 5 of Colts games (6) and 1 of Vikings games (5) finished above 41.5 combined points.
- Splits: Colts 1-2 on the road; Vikings 2-0 at home.
- Turnover margin: Colts -8, Vikings +6.
- Third down: Colts 37.4%, Vikings 38.0%.
- Red zone TD rate: Colts 63.2%, Vikings 50.0%.
Use these season numbers to read the Colts vs Vikings odds; they describe Indianapolis and Minnesota through six weeks and nothing more.
Byes so far: Minnesota (Week 6). That leaves that side with five games played rather than six.
Scoring gap: Indianapolis scores 24.0 and Minnesota allows 12.8; Minnesota scores 21.8 and Indianapolis allows 27.3, against a 41.5 total.
How the Colts vs Vikings Odds Have Moved
From the first DraftKings posting to 5:19 AM ET Tuesday, the spread shifted from Minnesota -3 to Minnesota -6.5 and the total went from 47.5 at the open to 41.5. On the moneyline, Minnesota went -162 to -278 and Indianapolis +136 to +225 in the Colts vs Vikings odds.
Current prices: Minnesota -6.5, Indianapolis +225, Minnesota -278, total 41.5, all from DraftKings via ESPN as of 5:19 AM ET on Tuesday, October 20, 2026.
Colts vs Vikings: Unit vs Unit
Indianapolis’s 215.0 passing yards per game run into the Minnesota pass defense allowing 195.4; on the ground it is 111.5 gained against 86.6 conceded. Points: 24.0 scored per game by Indianapolis, 12.8 allowed by Minnesota.
The other way, Minnesota scores 21.8 per game against the Indianapolis defense allowing 27.3. Pass rush: 10 sacks for Indianapolis, 17 for Minnesota. Those numbers are part of the backdrop for the Colts vs Vikings odds.
New to reading a line? The NFL odds guide covers the basics. The NFL category lists every preview, the most recent Colts preview and our previous Vikings preview add context on Indianapolis and Minnesota, and the free content hub gathers free daily content.
Colts vs Vikings: TV, Time & Venue
- Date: Sunday, October 25, 2026
- Kickoff: 1:00 PM ET
- Venue: U.S. Bank Stadium, Minneapolis, MN
- TV: CBS (NFL.com listing)
Tune in to CBS at 1:00 PM ET for the Sunday game from U.S. Bank Stadium. Live stats are on the ESPN gamecast.
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Informational only: the Minnesota vs Indianapolis numbers above come from ESPN, DraftKings and NFL.com and may change before kickoff. This is not gambling advice. Need help? Call 1-800-GAMBLER.
Frequently Asked Questions: Colts vs Vikings
What are the current Colts vs Vikings odds?
DraftKings has Minnesota at -6.5 with a total of 41.5; moneylines are Minnesota -278 and Indianapolis +225 (via ESPN, 5:19 AM ET Tuesday).
Where is Colts vs Vikings played?
The game is at U.S. Bank Stadium, Minneapolis, MN.
What time does Colts vs Vikings kick off?
Indianapolis and Minnesota kick off at 1:00 PM ET on Sunday, October 25, 2026.
How can I watch Colts vs Vikings?
It airs on CBS at 1:00 PM ET.