Our Colts vs Commanders preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 4 matchup between the Indianapolis Colts (1-2) and the Washington Commanders (1-2) on Sunday, October 4, 2026, at Tottenham Hotspur Stadium in London, England, a neutral-site international game with Washington as the designated home team. Kickoff is 9:30 AM ET (2:30 PM BST local time, 6:30 AM PT), and the game airs on NFL Network.
Week 4 storyline: Week 4 opens in London with two 1-2 teams coming off their first wins of the season. Washington will start Marcus Mariota for a second straight week after Dan Quinn ruled out Jayden Daniels (dislocated left elbow) on Friday. Indianapolis snapped a nine-game losing streak with a walk-off field goal against Houston, and the teams meet for the first time since Washington won 17-16 in Indianapolis in 2022 (ESPN).
As of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET), DraftKings via ESPN lists the Colts as 4.5-point favorites over the Commanders, with the moneyline at Colts -205 / Commanders +170 and the over/under at 47.5. Since the open, the spread has moved from WSH -1.5 to IND -4.5 and the total has moved from 48.5 to 47.5. Below are the full Colts vs Commanders odds, both team previews, the official Week 4 injury report and TV details.
Colts vs Commanders Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Indianapolis Colts vs Washington Commanders (London; Washington designated home) |
| Records | Colts 1-2 (0-1 road) · Commanders 1-2 (1-0 home) |
| Spread | Colts -4.5 (-105) · Commanders +4.5 (-115) |
| Moneyline | Colts -205 · Commanders +170 |
| Total | 47.5 (Over -108 / Under -112) |
| Venue | Tottenham Hotspur Stadium, London, England (neutral site) |
| Date/Time | Sunday, October 4, 2026 · 9:30 AM ET (2:30 PM BST local time, 6:30 AM PT) |
| TV | NFL Network |
| Head Coaches | Colts: Shane Steichen · Commanders: Dan Quinn |
| Quarterbacks | Colts: Daniel Jones · Commanders: Marcus Mariota (Jayden Daniels ruled out, elbow) |
Odds: DraftKings via ESPN as of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET). Opening line: WSH -1.5, total 48.5, moneyline Colts -110 / Commanders -110. Line movement: the spread has moved from WSH -1.5 to IND -4.5, and the total has moved from 48.5 to 47.5; the moneyline has gone from Colts -110 / Commanders -110 at the open to Colts -205 / Commanders +170. The DraftKings line has moved from IND -3.5 (total 47.5) since this preview first ran on Tuesday, Sept. 29. Lines can move before kickoff.
Indianapolis Colts Preview
Season so far: Indianapolis lost 41-23 at home to Baltimore, then lost 33-30 in overtime at Kansas City. In Week 3, Spencer Shrader, playing through a groin injury, kicked four field goals, including the winner with 16 seconds left, in a 19-17 victory over Houston. That ended the league’s longest active losing streak at nine games (AP). The Colts have scored 72 points and allowed 91, and AP noted the defense gave up more than 500 yards in each of the first two games.
Quarterback and key players: Daniel Jones is 65 of 98 for 611 yards with three touchdowns and three interceptions (ESPN). He fumbled three times against Houston and lost two. Jonathan Taylor has 258 rushing yards and four touchdowns. Josh Downs leads the team with 14 catches for 186 yards, and Keenan Allen scored his first touchdown as a Colt in Week 3. DeForest Buckner has three sacks and Akeem Davis-Gaither has 29 tackles.
This week: Taylor enters the game with 73 career rushing touchdowns, two shy of becoming the fifth player in NFL history to reach 75 before his 28th birthday (ESPN). Indianapolis went to Europe last November and beat Atlanta in Berlin (AP).
Washington Commanders Preview
Season so far: Washington lost 24-22 at Philadelphia when its tying two-point try was stopped, then lost 37-20 at Dallas, where Jayden Daniels dislocated his left elbow again. In Week 3 the Commanders ended defending champion Seattle’s 12-game winning streak, 33-31, as backup LB Kain Medrano returned an interception 50 yards for a touchdown with 3:57 left (AP). Washington has scored 75 points and allowed 92.
Quarterback and key players: Marcus Mariota threw three touchdown passes and no interceptions against Seattle and is 30 of 47 for 294 yards with four touchdowns this season (ESPN). Jacory Croskey-Merritt has 142 rushing yards. Terry McLaurin has 10 catches for 141 yards, rookie LB Sonny Styles had an interception in Week 3, and S Jeremy Reaves leads the team with 20 tackles.
This week: Daniels was limited in practice all week while wearing a brace, and Quinn ruled him out Friday, so he misses a second straight game. Quinn said the team wants to see Daniels get a full practice next week, with Week 5 against the Giants a possibility (ESPN, The Athletic). LB Frankie Luvu and TE Chig Okonkwo return after missing two games, while G Sam Cosmi and S Nick Cross did not travel to London (ESPN).
Colts vs Commanders Key Injuries
Source: the official final Week 4 injury reports released Friday, Oct. 2, as posted on NFL.com, with injured reserve moves from ESPN’s injury tracker and context from team sites and ESPN. Practice notes refer to Friday’s session. Players not listed below carry no game designation.
Indianapolis Colts — Out: none · Doubtful: none · Questionable: WR Keenan Allen (rest day, groin, did not practice Friday); WR Ashton Dulin (ankle, full Friday) · Injured reserve (ESPN): WR Alec Pierce (heel); DE Micheal Clemons (toe).
Washington Commanders — Out: G Sam Cosmi (concussion, throat); S Nick Cross (illness); QB Jayden Daniels (elbow); RB Rachaad White (shoulder) · Doubtful: none · Questionable: S Percy Butler (concussion, full Friday); WR Terry McLaurin (hamstring, limited Friday) · Injured reserve (ESPN): LB Leo Chenal (neck).
Context: McLaurin hurt his hamstring in practice this week. LB Leo Chenal had neck surgery after being carted off against Seattle and is on injured reserve (ESPN, WTOP).
Colts vs Commanders Key Matchup Notes
- London logistics: Kickoff is 2:30 PM local time (9:30 AM ET) at Tottenham Hotspur Stadium. Washington is the designated home team and the Colts the designated away team (Colts.com).
- Mariota’s second start: Mariota had four touchdown passes and no interceptions in his relief work and start so far, and he faces a defense that allowed 500-plus yards twice in September (ESPN, AP).
- Taylor vs the Washington front: Luvu is back for the Commanders. Taylor had 68 yards on 23 carries against Houston but has four rushing touchdowns.
- Turnovers: Washington forced three turnovers against Seattle, and Jones lost two fumbles against Houston.
- Market snapshot: DraftKings opened WSH -1.5 with a 48.5 total and now shows IND -4.5 and 47.5 (DraftKings via ESPN, as of 7:01 AM PT Saturday).
Kickoff, Venue & How to Watch Indianapolis Colts vs Washington Commanders
- Date: Sunday, October 4, 2026
- Kickoff: 9:30 AM ET (2:30 PM BST local time, 6:30 AM PT)
- Venue: Tottenham Hotspur Stadium, London, England (neutral site)
- TV / Streaming: NFL Network (national broadcast of the London game). NFL+ subscribers can also stream NFL Network, and ESPN lists the game in its NFL streaming hub
Where to watch: the Indianapolis Colts vs Washington Commanders game airs on NFL Network at 9:30 AM ET. This is the first of the 2026 NFL London Games; Eagles vs Jaguars follows at Tottenham Hotspur Stadium on Oct. 11 and Texans vs Jaguars at Wembley Stadium on Oct. 18 (ESPN). Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it does not offer betting advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET) for the Colts vs Commanders game on October 4, 2026.