Thursday night at Xfinity Mobile Arena brings the Cleveland Cavaliers to Philadelphia, PA to face the Philadelphia 76ers at 7:00 PM ET (4:00 PM MST). Below you will find the full Cavaliers vs 76ers odds from DraftKings, plus storylines, injuries and key players for both sides.
Cavaliers vs 76ers odds: Lines, Venue and TV
| Matchup | Cleveland Cavaliers at Philadelphia 76ers |
|---|---|
| Records (2026-27) | Cavaliers 0-0 | 76ers 1-0 |
| 2025-26 records | Cavaliers 52-30 | 76ers 45-37 |
| Spread | 76ers -2.5 (-110) / Cavaliers +2.5 (-110) |
| Moneyline | Cavaliers +114 / 76ers -135 |
| Total | O/U 234.5 (over -112, under -108) |
| Venue | Xfinity Mobile Arena, Philadelphia, PA |
| Date | Thursday, October 22, 2026 |
| Time | 7:00 PM ET (4:00 PM MST) |
| TV | ESPN |
Lines in the table come from DraftKings (through ESPN) and were captured Wed Oct 21 2026 10:49 AM MST; prices move, so check again near game time.
Opening Numbers vs. Current Prices
The Cavaliers vs 76ers odds opened with the 76ers at -4.5 and the home side now sits at -2.5, a shift of 2 points since the open. On the moneyline, the Cavaliers went from +145 at the open to +114, while the 76ers moved from -175 to -135. The total opened at 233.5 and is 234.5 now, a move of 1 point.
Converted to implied probability, Cavaliers at +114 works out to 46.7% and 76ers at -135 to 57.4%, with the difference above 100% reflecting the sportsbook margin. The 76ers hold favorite status in the current Cavaliers vs 76ers odds.
What to Know Before Cavaliers vs. 76ers
The Cleveland Cavaliers finished 2025-26 at 52-30 (27-14 at home, 25-16 on the road), the No. 4 seed in the Eastern Conference, scoring 119.5 points per game and allowing 115.4 for a +4.1 average margin. They closed the season 7-3 over their last 10 games under head coach Kenny Atkinson. That backdrop matters for the Cavaliers vs 76ers odds.
The Philadelphia 76ers finished 2025-26 at 45-37 (23-18 at home, 22-19 on the road), the No. 7 seed in the Eastern Conference, scoring 115.9 points per game and allowing 116.1 for a -0.2 average margin. Head coach Nick Nurse saw the club go 6-4 across its final 10 contests. Health news like this often feeds into the Cavaliers vs 76ers odds.
Head-to-head from 2025-26: Nov 6: Cavaliers 132-121; Jan 15: Cavaliers 133-107; Jan 17: Cavaliers 117-115; Mar 9: Cavaliers 115-101. That added up to a 0-4 mark for the 76ers. This is the first of the 2026-27 regular-season meetings, and the Cavaliers vs 76ers odds reflect a fresh slate for both clubs.
ESPN’s game page frames the night simply: "Philadelphia faces conference foe Cleveland." Last season’s resume, the first week of results and the health report are the main inputs available this early. Roster turnover is one reason the Cavaliers vs 76ers odds look the way they do.
The Cavaliers open their 2026-27 regular season in this game, so they come in at 0-0 and fully rested. The 76ers are 1-0 after a 106-100 win at the New York Knicks on Tuesday, Oct 20, which gives them 1 day of rest and no back-to-back; they did not play on Wednesday, Oct 21. Those numbers are a useful lens on the Cavaliers vs 76ers odds.
Recent Form
Cleveland Cavaliers preseason results: L 124-113 vs. Boston Celtics; W 119-105 vs. Orlando Magic; L 132-116 at Orlando Magic. The record was 1-2, with a scoring average of 116.0 against 120.3 conceded.
October exhibition results for the 76ers read W 120-97 vs. New York Knicks; L 114-108 at Brooklyn Nets; L 144-106 at Boston Celtics; L 125-120 OT vs. Boston Celtics, a 1-3 run in which they put up 113.5 per game and gave up 120.0.
Rotations in the preseason tend to be fluid, so these scores are context rather than a verdict, and the same goes for a 1-0 or 0-0 start.
Cavaliers and 76ers Injuries
Cleveland Cavaliers: Sam Merrill (G, Elbow) is listed as day-to-day; Nae’Qwan Tomlin (F, Back) is listed as out, with an estimated return of Nov 16, 2026; Khalifa Diop (C, Knee) is listed as day-to-day.
Philadelphia 76ers: Tacko Fall (C, Hip) is listed as day-to-day; Dean Wade (F, Ankle) is listed as day-to-day; Dominick Barlow (F, Back) is listed as out, with an estimated return of Nov 2, 2026; Ariel Hukporti (C, Achilles) is listed as out, with an estimated return of Oct 1, 2027.
Final statuses are often confirmed close to tipoff, so watch for movement in the Cavaliers vs 76ers odds if a listed player is ruled in or out.
Rotation and Personnel
Among players still on the current roster, the Cavaliers’ top 2025-26 per-game marks on ESPN’s leader board belong to Donovan Mitchell in points (27.9) and assists (5.7) and Evan Mobley in rebounds (9.0). Evan Mobley (18.2 ppg) and Jarrett Allen (15.4 ppg) also return as scoring options.
ESPN’s current Cavaliers roster lists 17 players: Jarrett Allen, Thomas Bryant, Khalifa Diop, Tristan Enaruna, James Harden, Mario Hezonja, Sam Merrill, Riley Minix, Donovan Mitchell, Evan Mobley, Craig Porter Jr., Tyrese Proctor, Meleek Thomas, Nae’Qwan Tomlin, Jaylon Tyson, Ernest Udeh Jr. and Peyton Watson. First-year players include Khalifa Diop, Meleek Thomas and Ernest Udeh Jr..
Among players still on the current roster, the 76ers’ top 2025-26 per-game marks on ESPN’s leader board belong to Tyrese Maxey in points (28.3) and assists (6.6) and VJ Edgecombe in rebounds (5.6). VJ Edgecombe (16.0 ppg) and Dominick Barlow (7.7 ppg) also return as scoring options.
ESPN’s current 76ers roster lists 17 players: Dominick Barlow, Adem Bona, Jaylen Brown, Kentavious Caldwell-Pope, VJ Edgecombe, Justin Edwards, Joel Embiid, Tacko Fall, Ariel Hukporti, LeBron James, Caleb Love, Tyrese Maxey, Labaron Philon Jr., Rayan Rupert, Anfernee Simons, Dean Wade and Jabari Walker. First-year players include Labaron Philon Jr..
How to Watch Cavaliers vs. 76ers
Coverage is on ESPN. The ball goes up at 7:00 PM ET (4:00 PM MST) in Philadelphia, PA. For live box scores and play-by-play, the ESPN game page carries the official feed.
Browse every game on the NBA category page or visit the free content hub for more daily previews. For in-depth premium content, see Cappers Direct Premium.
Frequently Asked Questions: Cavaliers vs. 76ers
What are the Cavaliers vs 76ers odds?
As of Wed Oct 21 2026 10:49 AM MST, DraftKings lists the spread at 76ers -2.5 (-110) / Cavaliers +2.5 (-110), the moneyline at Cavaliers +114 / 76ers -135 and the total at 234.5 (over -112, under -108).
What time does Cavaliers vs. 76ers start and what channel is it on?
Tipoff is 7:00 PM ET (4:00 PM MST) on Thursday, October 22, 2026, at Xfinity Mobile Arena in Philadelphia, PA. The broadcast is on ESPN.
Who is on the injury report for Cavaliers vs. 76ers?
Cavaliers: Sam Merrill (day-to-day), Nae’Qwan Tomlin (out) and Khalifa Diop (day-to-day); 76ers: Tacko Fall (day-to-day), Dean Wade (day-to-day), Dominick Barlow (out) and Ariel Hukporti (out), per ESPN.
How did the Cavaliers and 76ers finish last season?
The Cavaliers went 52-30 in 2025-26 and the 76ers went 45-37, per ESPN standings.
Have the Cavaliers vs 76ers odds moved since opening?
The home spread opened at -4.5 and is -2.5 now; the total opened at 233.5 and sits at 234.5.