Our Cardinals vs Giants preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 4 matchup between the Arizona Cardinals (1-2) and the New York Giants (2-1) on Sunday, October 4, 2026, at MetLife Stadium in East Rutherford, NJ. Kickoff is 1:00 PM ET (10:00 AM PT), and the game airs on CBS.
Week 4 storyline: Two first-year head coaches meet at MetLife Stadium, and two veteran quarterbacks who go back to their college days, Jacoby Brissett and Jameis Winston, start against each other (AP). John Harbaugh’s Giants are 2-1 but lost QB Jaxson Dart and pass rusher Brian Burns to season-altering knee injuries, then traded for J.J. McCarthy on Monday. Harbaugh has reaffirmed Winston as the starter.
As of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET), DraftKings via ESPN lists the Cardinals as 2.5-point favorites over the Giants, with the moneyline at Cardinals -142 / Giants +120 and the over/under at 44.5. Since the open, the spread has moved from NYG -7 to ARI -2.5 and the total has moved from 45.5 to 44.5. Below are the full Cardinals vs Giants odds, both team previews, the official Week 4 injury report and TV details.
Cardinals vs Giants Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Arizona Cardinals at New York Giants |
| Records | Cardinals 1-2 (1-1 road) · Giants 2-1 (2-0 home) |
| Spread | Cardinals -2.5 (-112) · Giants +2.5 (-108) |
| Moneyline | Cardinals -142 · Giants +120 |
| Total | 44.5 (Over -108 / Under -112) |
| Venue | MetLife Stadium, East Rutherford, NJ |
| Date/Time | Sunday, October 4, 2026 · 1:00 PM ET (10:00 AM PT) |
| TV | CBS |
| Head Coaches | Cardinals: Mike LaFleur · Giants: John Harbaugh |
| Quarterbacks | Cardinals: Jacoby Brissett · Giants: Jameis Winston (Jaxson Dart on IR) |
Odds: DraftKings via ESPN as of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET). Opening line: NYG -7, total 45.5, moneyline Cardinals +260 / Giants -325. Line movement: the spread has moved from NYG -7 to ARI -2.5, and the total has moved from 45.5 to 44.5; the moneyline has gone from Cardinals +260 / Giants -325 at the open to Cardinals -142 / Giants +120. The DraftKings line has moved from ARI -1.5 (total 44.5) since this preview first ran on Tuesday, Sept. 29. Lines can move before kickoff.
Arizona Cardinals Preview
Season so far: Arizona won 26-14 at the Chargers in LaFleur’s debut as the NFL’s biggest Week 1 underdog. The Cardinals then lost 31-7 to Seattle, managing 151 total yards, and 36-30 at San Francisco in Week 3, a game in which they drew 10 penalties (AP). They have lost 22 of their last 26 division games. Arizona has scored 63 points and allowed 81.
Quarterback and key players: Jacoby Brissett is 82 of 117 for 652 yards with four touchdowns and one interception, and he threw for 280 yards and two scores in Week 3 (ESPN). Jeremiyah Love has 160 rushing yards. Trey McBride leads the team with 26 catches for 211 yards and two touchdowns. Budda Baker has 1.5 sacks and Jack Gibbens has 24 tackles.
This week: ESPN profiled Bill Parcells’ long mentorship of Brissett, which dates to Brissett’s high school years. S Dadrion Taylor-Demerson (back) did not practice all week and is out, leaving Wydett Williams as the only active reserve safety, per the Cardinals’ official site via ESPN.
New York Giants Preview
Season so far: New York beat Dallas 28-20 in Harbaugh’s debut, then lost 28-6 at the Rams after Dart hurt his left knee on the seventh snap. In Week 3 the Giants beat Tennessee 12-7 in rain and wind, with Jevon Holland intercepting a pass in the end zone with 17 seconds left, his interception in a third straight game (AP). They are 2-0 at home and have scored 46 points while allowing 55.
Quarterback and key players: Dart had surgery to repair the meniscus and MCL in his left knee (The Athletic) and is on IR. Jameis Winston has started in his place and had no turnovers in the win over Tennessee. Matt Nagy is the offensive coordinator. Cam Skattebo has 177 rushing yards, and Isaiah Likely leads the team with 15 catches and two touchdowns. LB Arvell Reese has 25 tackles.
This week: The Giants acquired McCarthy from Minnesota for a 2027 fifth-round draft choice, and Harbaugh would not say whether he will be the No. 2 or No. 3 quarterback this week; Jake Haener backed up Winston in Week 3 (ESPN, Newsday). New York also released WR Odell Beckham Jr. on Tuesday.
Cardinals vs Giants Key Injuries
Source: the official final Week 4 injury reports released Friday, Oct. 2, as posted on NFL.com, with injured reserve moves from ESPN’s injury tracker and context from team sites and ESPN. Practice notes refer to Friday’s session. Players not listed below carry no game designation.
Arizona Cardinals — Out: S Dadrion Taylor-Demerson (back) · Doubtful: none · Questionable: LB Josh Sweat (rest day, groin, limited Friday) · Injured reserve (ESPN): CB Will Johnson (neck).
New York Giants — Out: none · Doubtful: none · Questionable: none · Injured reserve (ESPN): QB Jaxson Dart (knee – meniscus); LB Brian Burns (knee – ACL).
Context: The Giants have no player with a game designation on the final report. S Tyler Nubin and CB Deonte Banks, both listed as out earlier in the week, were full participants Friday. C John Michael Schmitz did not practice Friday but has no designation, and Brian Burns (torn ACL) is out for the season (Giants.com).
Cardinals vs Giants Key Matchup Notes
- Brissett vs Winston: Two veteran starters who first crossed paths in college meet as starters at MetLife Stadium (AP).
- Giants ground game: With Winston at quarterback, New York ran for 138 yards and had no turnovers against Tennessee.
- McBride vs a healthier secondary: Nubin and Banks are off the injury report for New York, while CB Paulson Adebo remains on IR.
- Pass rush without Burns: Abdul Carter and the rest of the Giants front try to generate pressure without Burns, who was second in the NFL in sacks last season (AP).
- Market snapshot: DraftKings opened NYG -7 with a 45.5 total and now shows ARI -2.5 and 44.5 (DraftKings via ESPN, as of 7:01 AM PT Saturday).
Kickoff, Venue & How to Watch Arizona Cardinals vs New York Giants
- Date: Sunday, October 4, 2026
- Kickoff: 1:00 PM ET (10:00 AM PT)
- Venue: MetLife Stadium, East Rutherford, NJ
- TV / Streaming: CBS (regional broadcast; check local listings). Streaming: Paramount+ carries the local CBS feed, NFL+ streams local games on phones and tablets, and out-of-market viewers can use NFL Sunday Ticket on YouTube / YouTube TV
Where to watch: the Arizona Cardinals vs New York Giants game airs on CBS at 1:00 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it does not offer betting advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Saturday, Oct. 3, 2026, 7:01 AM PT (10:01 AM ET) for the Cardinals vs Giants game on October 4, 2026.