With a 43.5-point total and Denver listed at -4.5, the Broncos vs Cardinals odds frame a Sunday meeting between the Denver Broncos (4-2) and the Arizona Cardinals (2-4). The game kicks off at 4:05 PM ET at State Farm Stadium on CBS.
Before the details, a scoring snapshot: Denver 114 for and 125 against, Arizona 126 for and 178 against.
Broncos vs Cardinals Odds at a Glance
| Matchup | Denver Broncos at Arizona Cardinals |
| Records | Broncos 4-2 (1-2 road), Cardinals 2-4 (0-2 home) |
| Spread | Broncos -4.5 (-110), Cardinals +4.5 (-110) |
| Moneyline | Broncos -230, Cardinals +190 |
| Total | 43.5 (Over -115, Under -105) |
| Venue | State Farm Stadium, Glendale, AZ |
| Date | Sunday, October 25, 2026 |
| Kickoff | 4:05 PM ET |
| TV | CBS |
The Broncos vs Cardinals odds in this table are DraftKings numbers via ESPN as of 5:19 AM ET on Tuesday, October 20, 2026; prices in parentheses, and lines can move before kickoff.
Broncos Preview: 4-2 Heading to Glendale
First, the road team in the Broncos vs Cardinals odds. The record reads 4-2 for Denver, with a mark of 1-2 on the road. Week 6 ended with Denver posting 17 points against the Seattle Seahawks and giving up 14, a win. Denver has now strung together two straight wins. Denver owns a -11 point differential, built on 114 scored and 125 allowed.
Results so far:
- Week 1: L 10-31 at Kansas City Chiefs
- Week 2: W 20-13 vs. Jacksonville Jaguars
- Week 3: W 30-26 vs. Los Angeles Rams
- Week 4: L 14-24 at San Francisco 49ers
- Week 5: W 23-17 at Los Angeles Chargers
- Week 6: W 17-14 vs. Seattle Seahawks
ESPN’s statistical leaders for Denver: Bo Nix is Denver’s passing leader at 114/189, 1,049 YDS, 6 TD, 3 INT. J.K. Dobbins carries the rushing load (81 CAR, 270 YDS, 2 TD). The top target has been Jaylen Waddle (22 REC, 228 YDS, 1 TD). Zach Allen tops the sack chart at 4.5, while Alex Singleton has a team-high 68 tackles.
The Denver offense produces 19.0 points per outing on 259.0 yards (174.8 passing, 84.2 rushing). Inside the 20, Denver scores touchdowns 61.1% of the time, and it moves the chains on 31.6% of third downs (5.6 per pass, 3.4 per rush).
Denver concedes 20.8 points a game; the yardage allowed is 230.0 passing and 139.8 rushing per game. Turnovers: 10 forced and 6 lost by Denver, a +4 margin. The pass rush has 18 sacks. Denver has made 9-12 on field goal tries.
Cardinals Preview: Results & Team Stats
Arizona is the home side in the Broncos vs Cardinals odds. Arizona Cardinals come into this one at 2-4, including 0-2 at home. Arizona played the Los Angeles Rams last, a 18-16 win on the road. The scoreboard math for Arizona: 126 points for, 178 against, -52 net.
Results so far:
- Week 1: W 26-14 at Los Angeles Chargers
- Week 2: L 7-31 vs. Seattle Seahawks
- Week 3: L 30-36 at San Francisco 49ers
- Week 4: L 24-36 at New York Giants
- Week 5: L 21-45 vs. Detroit Lions
- Week 6: W 18-16 at Los Angeles Rams
Scoring 21.0 points a game, Arizona moves the ball for 318.8 yards per contest, 96.3 of them on runs. Arizona converts 39.3% of third downs and finishes 47.8% of red-zone trips with touchdowns, at 5.7 yards per throw and 3.7 per rush.
ESPN’s statistical leaders for Arizona: Jacoby Brissett is Arizona’s passing leader at 156/234, 1,328 YDS, 9 TD, 6 INT. Jeremiyah Love carries the rushing load (67 CAR, 245 YDS, 1 TD). The top target has been Trey McBride (49 REC, 361 YDS, 3 TD). Budda Baker tops the sack chart at 3.5, while Mack Wilson Sr. has a team-high 44 tackles.
Against Arizona, offenses average 29.7 points and 368.2 total yards. Arizona has 14 sacks, has allowed 12, and sits at +2 in turnover margin (8 takeaways, 6 giveaways). On field goals Arizona is 14-16.
Broncos & Cardinals Injury Report
Availability matters for the Broncos vs Cardinals odds. ESPN’s report (2026-10-20 09:19 UTC) shows the statuses below for Denver and Arizona; team practice reports arrive later in the week.
Broncos Injury Report
- Out: CB Pat Surtain II (ankle sprain); S Talanoa Hufanga (ankle)
- Questionable: RB Tyler Badie (thumb)
- Injured reserve (most recent): WR Pat Bryant (ankle sprain)
Cardinals Injury Report
- Out: RB Jeremiyah Love (ankle); S Wydett Williams Jr. (concussion); S Andrew Wingard (knee bruise)
- Injured reserve (most recent): RB James Conner (foot surgery)
Broncos vs Cardinals Statistical Matchup
Arizona allows 29.7 points a game; Denver scores 19.0. Arizona gives up 120.8 rushing yards per game, and Denver gains 84.2. Through the air, 174.8 meets 247.3.
The other way, Arizona scores 21.0 per game against the Denver defense allowing 20.8. Pass rush: 18 sacks for Denver, 14 for Arizona. Those numbers are part of the backdrop for the Broncos vs Cardinals odds.
How the Broncos vs Cardinals Odds Have Moved
The Broncos vs Cardinals odds have a history already: there has been no total movement from 43.5, and the spread shifted from Denver -7.5 to Denver -4.5. Denver moneyline -360 to -230; Arizona +285 to +190.
As of 5:19 AM ET on Tuesday, October 20, 2026, the spread is Denver -4.5 and the total 43.5; Arizona is +190 and Denver -230 on the moneyline.
Broncos vs Cardinals Odds: Trends & Numbers
- Totals: 1 of Broncos games (6) and 3 of Cardinals games (6) finished above 43.5 combined points.
- Splits: Broncos 1-2 on the road; Cardinals 0-2 at home.
- Turnover margin: Broncos +4, Cardinals +2.
- Third down: Broncos 31.6%, Cardinals 39.3%.
- Red zone TD rate: Broncos 61.1%, Cardinals 47.8%.
These are past results only, listed as context for the Broncos vs Cardinals odds and not as a forecast.
The season scoring averages (Denver 19.0 for, 20.8 against; Arizona 21.0 for, 29.7 against) sit well apart, which is part of the backdrop for the 43.5 total.
Where to Watch Broncos vs Cardinals
- Date: Sunday, October 25, 2026
- Kickoff: 4:05 PM ET
- Venue: State Farm Stadium, Glendale, AZ
- TV: CBS (NFL.com listing)
Tune in to CBS at 4:05 PM ET for the Sunday game from State Farm Stadium. Live stats are on ESPN’s game page.
For background, see our previous Broncos preview and last week’s Arizona preview. The NFL category has the rest of the slate, the free content hub collects our free coverage, and the NFL odds guide explains how lines are priced.
Our NFL packages, including deeper work on games like Denver at Arizona, come with Cappers Direct Premium; the Broncos vs Cardinals odds here are the free starting point.
This Denver-Arizona preview reports DraftKings odds via ESPN, ESPN injury and team data, and NFL.com broadcast listings. It is information, not gambling advice; odds and statuses can change. If you gamble, do so legally and responsibly (1-800-GAMBLER).
Broncos at Cardinals: Frequently Asked Questions
Where do the Broncos vs Cardinals odds stand?
The Broncos vs Cardinals odds: spread Denver -4.5, total 43.5, moneyline Denver -230 / Arizona +190, per DraftKings via ESPN at 5:19 AM ET Tuesday.
What channel is Broncos vs Cardinals on?
It airs on CBS at 4:05 PM ET.
What time does Broncos vs Cardinals kick off?
The game starts at 4:05 PM ET, Sunday, October 25, 2026, at State Farm Stadium.
Where is the Broncos at Cardinals game?
State Farm Stadium in Glendale hosts it.