Our Milwaukee Brewers vs San Diego Padres preview covers the odds, run line, moneyline, total, probable pitchers, first pitch time, TV channel and where to watch for Game 4 of the National League Division Series (NLDS) on Wednesday, October 7, 2026. The No. 1-seeded Milwaukee Brewers (103-59) and the No. 4-seeded San Diego Padres (91-71) meet at Petco Park in San Diego, Calif., where the Brewers lead the best-of-five series 2-1 and the Padres face elimination. First pitch is 10:00 PM ET (7:00 PM PT). TV: FS1 / FOX One.
Division Series storyline: Milwaukee rallied from 2-0 deficits in both games at American Family Field, winning Game 1 3-2 on Contreras’ seventh-inning homer and Game 2 4-3 on Chourio’s walk-off single. San Diego stayed alive with a 4-3 win in Game 3 at Petco Park on Tuesday night (MLB Stats API). The Padres won the regular-season series 4-2, including a three-game sweep at Petco Park on Aug. 10-12 (MLB Stats API). San Diego placed closer Mason Miller on the paternity list Tuesday and activated left-hander Wandy Peralta (MLB Stats API). Neither team had announced a probable pitcher (the MLB Stats API lists none). DraftKings lists the Padres at -116 on the moneyline and the Brewers at -104, with the total at 7.5.
Milwaukee Brewers vs San Diego Padres Odds, Run Line & Game Info
| Matchup | Milwaukee Brewers @ San Diego Padres |
|---|---|
| Series | National League Division Series (NLDS), Game 4 — best-of-five, 2-2-1 format |
| Series Score | Brewers lead 2-1. Game 1: Brewers won 3-2 (Saturday, Oct. 3). Game 2: Brewers won 4-3 (Sunday, Oct. 4). Game 3: Padres won 4-3 (Tuesday, Oct. 6). Remaining: Game 5 (if necessary): Friday, Oct. 9, 4:30 PM ET at American Family Field |
| Seeds | Milwaukee Brewers No. 1 | San Diego Padres No. 4 (NL) |
| 2026 Records | Milwaukee Brewers 103-59 (48-33 on the road) | San Diego Padres 91-71 (51-30 at home) |
| How They Got Here | Brewers: First-round bye as NL Central champion and No. 1 seed | Padres: Swept the No. 5 Chicago Cubs 2-0 in the NL Wild Card Series (8-0, 4-1) |
| Run Line | Brewers -1.5 (+165) | Padres +1.5 (-202) |
| Moneyline | Milwaukee Brewers: -104 | San Diego Padres: -116 |
| Total | O/U 7.5 (Over +102 / Under -123) |
| Probable Pitchers | Brewers: TBD (not announced) | Padres: TBD (not announced) |
| Managers | Milwaukee Brewers: Pat Murphy | San Diego Padres: Craig Stammen |
| Venue | Petco Park (San Diego, Calif.) |
| Date / Time | Wednesday, October 7, 2026 — 10:00 PM ET (7:00 PM PT) |
| TV / How to Watch | FS1 / FOX One (Spanish: FOX Deportes) |
| 2026 Season Series | Padres won the 2026 season series 4-2 |
Odds via DraftKings (through ESPN) as of Wednesday, Oct. 7, 2026, 1:33 AM ET. Opening line: Brewers -103 / Padres -116, total 7.5. Lines move, so check your sportsbook before first pitch.
Brewers vs Padres NLDS Series Context
Format: The NLDS is a best-of-five series in a 2-2-1 format. Games 1 and 2 were at American Family Field, Games 3 and 4 are at Petco Park in San Diego, and a deciding Game 5 would return to Milwaukee. The remaining schedule is in the table above (MLB Stats API).
Game 1 recap: William Contreras hit a tiebreaking solo homer off Adrian Morejon (L) with two outs in the seventh inning, and the Brewers beat the Padres 3-2 at American Family Field on Saturday night after Jackson Chourio’s two-run homer off Robbie Ray erased a 2-0 deficit in the third. DL Hall (W) escaped a bases-loaded jam in the seventh, Trevor Megill got the final four outs for the save, and Ty France’s deep drive in the ninth hit a roof cable and was caught by Chourio, with the out upheld on review (MLB.com). San Diego outhit Milwaukee 9-7 but went 1-for-9 with runners in scoring position (MLB Stats API box score).
Game 2 recap: Chourio’s two-out, two-run single off Mason Miller (L) in the bottom of the ninth gave Milwaukee a 4-3 walk-off win on Sunday. Michael King retired the first 14 Brewers he faced and allowed one run in five innings, France drove in two runs with two-out singles, and the teams combined for five errors and three unearned runs (ESPN, MLB Stats API). Miller entered with a 3-2 lead for a six-out save, struck out two in a perfect eighth, then walked Christian Yelich, Sal Frelick and pinch hitter Gary Sánchez in the ninth before Chourio lined his 40th pitch up the middle (AP, MLB.com). Megill (W) threw a perfect ninth.
Game 3 recap: San Diego beat Milwaukee 4-3 at Petco Park on Tuesday night. Decisions: W Yuki Matsui, L JoJo Romero, S Michael King. Starters: Dustin May (3 IP, 3 H, 2 ER, 2 BB, 3 K, 52 pitches) for Milwaukee and Nick Pivetta (4 1/3 IP, 5 H, 2 ER, 0 BB, 4 K, 69 pitches) for San Diego. Scoring: Fernando Tatis Jr in the bottom of inning 3; Manny Machado singles on a ground ball to left fielder Jackson Chourio in the bottom of inning 3; William Contreras homers (2) on a fly ball to left field in the top of inning 4; Jackson Chourio out on a sacrifice fly to left fielder Dustin Harris in the top of inning 5; Jake Cronenworth homers (1) on a fly ball to right field in the bottom of inning 5; Miguel Andujar reaches on a throwing error by shortstop Cooper Pratt in the bottom of inning 6; and more. (MLB Stats API box score and play-by-play.)
How they got here: San Diego swept the Cubs at Petco Park in the Wild Card Series, 8-0 behind seven one-hit innings from King and 4-1 behind Gavin Sheets’ two-run homer. Milwaukee went 8-2 in its last 10 regular-season games, and MLB.com noted the Brewers won 42 regular-season games in come-from-behind fashion (MLB Stats API, MLB.com).
Head-to-head: San Diego went 4-2 against Milwaukee in 2026. The Brewers won two of three at American Family Field in May, and the Padres swept three at Petco Park on Aug. 10-12 (3-2, 11-2 and 4-3) (MLB Stats API). This is the first postseason meeting between the franchises (FOX Sports).
Milwaukee Brewers Preview: NLDS Game 4
Season in review: Manager Pat Murphy‘s Brewers went 103-59, the best record in the majors, including 55-26 at home and 48-33 on the road. Milwaukee scored 832 runs and allowed 618, hit .258 with a .744 OPS and a .341 on-base percentage, stole 162 bases and posted a 3.51 team ERA with 55 saves (MLB Stats API). Jake Bauers led the club with 26 homers and an .873 OPS, Chourio hit .291 with 25 homers and 23 steals, Brice Turang drove in 100 runs and Contreras drove in 94 (MLB Stats API team leaders).
Lineup notes: MLB.com listed the Game 2 lineup against King as a reference: Chourio (LF), Turang (2B), Bauers (1B), Contreras (C), Garrett Mitchell (CF), Yelich (DH), Frelick (RF), Cooper Pratt (SS) and David Hamilton (3B). Chourio drove in two runs in each of the first two games, and MLB.com noted he has 15 career postseason RBIs, second in Brewers history to Ryan Braun’s 16. Joey Ortiz (abdominal, groin, right knee) sat out Game 2 for what MLB.com described as matchup reasons.
Bullpen and injuries: Milwaukee’s relievers did not allow an earned run over nine innings in Games 1 and 2, with Megill, Abner Uribe and Aaron Ashby pitching in both (MLB Stats API). Left-handers Robert Gasser, Shane Drohan and Kyle Harrison give Murphy length options (MLB.com). ESPN lists RHPs Brandon Woodruff and Quinn Priester (shoulder, 60-day IL), relievers Angel Zerpa and Brian Fitzpatrick (elbow surgery, 60-day IL) and RHP Grant Anderson (biceps, 15-day IL).
San Diego Padres Preview: NLDS Game 4
Season in review: Under manager Craig Stammen, the Padres went 91-71, finished second in the NL West and earned the NL’s No. 4 seed. They were 51-30 at Petco Park and 40-41 on the road. San Diego scored 722 runs and allowed 681, hit .244 with a .717 OPS, stole 164 bases and posted a 3.99 team ERA with 48 saves (MLB Stats API). Manny Machado led the club with 30 homers and 91 RBIs, Fernando Tatis Jr. hit .289 with 25 homers and 38 steals, and Miller had 38 saves in 41 chances with a 1.67 ERA (MLB Stats API, ESPN).
Lineup notes: MLB.com’s projected Game 3 lineup was Tatis (RF), Dustin Harris (LF), Machado (3B), France (1B), Jackson Merrill (CF), Sheets (DH), Xander Bogaerts (SS), Ethan Salas (C) and Jake Cronenworth (2B). France had seven hits in his first 15 postseason at-bats, while Cronenworth was 1-for-13 entering Game 3 (MLB.com). ESPN lists Sheets as day-to-day with neck soreness.
Bullpen and injuries: Miller was placed on the paternity list Tuesday, with left-hander Wandy Peralta activated in his place (MLB Stats API); ESPN lists Oct. 9 as his return date. Morejon, Bradgley Rodriguez, Jason Adam and Yuki Matsui are the other late-inning options, and Walker Buehler, back from the paternity list Monday, is available in relief (MLB.com). RHP Jeremiah Estrada (shoulder) remains out, and ESPN also lists RHP Lucas Giolito (elbow, 60-day IL) and DH Miguel Andujar (wrist, 10-day IL).
Starting Pitchers: Not Yet Announced
Brewers: TBD. Milwaukee had not named a Game 4 starter, and the MLB Stats API and ESPN list no probable. Jacob Misiorowski (16-5, MLB-leading 1.80 ERA, 252 strikeouts and 0.80 WHIP) started Game 1 on Saturday and allowed two runs in four innings (88 pitches), Logan Henderson started Game 2 (5 IP, 1 ER), and Dustin May started Game 3 (MLB Stats API, MLB.com). Before the series, MLB.com listed left-handers Gasser (1.67 ERA over his final six outings), Drohan (as an opener) and Harrison as Milwaukee’s other starting options, and noted the Brewers used openers three times in nine postseason games in 2025.
Padres: TBD. San Diego had not named a Game 4 starter either. Robbie Ray started Game 1 (2 2/3 IP, 2 ER, 45 pitches), Michael King started Game 2 (5 IP, 1 ER, 72 pitches) and Nick Pivetta started Game 3 (MLB Stats API). MLB.com wrote before the series that Ray starting Game 1 could leave Buehler for Game 4, although Buehler could also be used for length out of the bullpen, and King would be on regular rest for a potential Game 5.
Key Matchup Notes: Brewers vs Padres Game 4
- Late innings: Milwaukee scored its go-ahead runs in the seventh inning or later in Games 1 and 2, against Morejon and Miller, and San Diego will be without Miller while he is on the paternity list (MLB Stats API, MLB.com).
- Bullpens: In Game 2, San Diego followed King (72 pitches) with Matsui (27), Rodriguez (13) and Miller (40), and Milwaukee followed Henderson (72) with JoJo Romero (15), Uribe (26), Ashby (12) and Megill (9) (MLB Stats API). In Game 3, Milwaukee used Dustin May (52), JoJo Romero (30), Antonio Senzatela (14), DL Hall (29), Abner Uribe (7), and San Diego used Nick Pivetta (69), Jason Adam (13), Yuki Matsui (23), Bradgley Rodriguez (21), Michael King (40) (pitch counts in parentheses; MLB Stats API).
- Close games: Games 1 and 2 were decided by one run, and San Diego went 3-for-18 with runners in scoring position in those games while Milwaukee went 4-for-16 (MLB Stats API box scores). DraftKings lists the Game 4 total at 7.5.
How to Watch Milwaukee Brewers vs San Diego Padres – NLDS Game 4
Date: Wednesday, October 7, 2026
First pitch: 10:00 PM ET (7:00 PM PT)
Venue: Petco Park, San Diego, Calif.
TV / Streaming: FS1 and FOX One, with Spanish-language coverage on FOX Deportes (MLB Stats API, MLB.com). In the U.S., the game is also available on MLB.TV with authentication to a participating pay-TV provider, and Sportsnet carries it in Canada (MLB.com).
The series winner advances to the NLCS against the winner of the Dodgers-Braves NLDS. If San Diego wins Wednesday, a deciding Game 5 would be Friday, Oct. 9 at 4:30 p.m. ET at American Family Field (MLB Stats API). Check the run line, moneyline and total above against your sportsbook before the October 7, 2026 first pitch, and look for official lineups closer to game time.