Astros vs. Mariners Preview: Odds, Spread, Time & TV (September 22, 2026)

The Houston Astros (77-79) visit the Seattle Mariners (73-83) on Tuesday, September 22, 2026 at T-Mobile Park. First pitch is set for 9:40 PM ET. TV: MLB.TV / Space City Home Network / Mariners.TV.

Houston Astros vs Seattle Mariners Odds & Preview Info

Matchup Houston Astros @ Seattle Mariners
Records Houston Astros 77-79 | Seattle Mariners 73-83
Run Line HOU +1.5 | SEA -1.5
Moneyline Houston Astros: +124 | Seattle Mariners: -150
Total 7.5
Venue T-Mobile Park
Date / Time Tuesday, September 22, 2026 — 9:40 PM ET
TV / How to Watch MLB.TV / Space City Home Network / Mariners.TV
Probable Pitchers Houston Astros: Cristian Javier (2-6, 5.31) | Seattle Mariners: Logan Gilbert (12-10, 3.69)

Odds shown via public sportsbooks (lines move — verify before betting).

Houston Astros Preview & Probable Pitcher

The Houston Astros enter Tuesday at 77-79 and travel to face the Seattle Mariners at T-Mobile Park. Slated starter: Cristian Javier (2-6, 5.31).

Track the run line, moneyline, and total listed above for this odds preview. Double-check probable pitchers and any late roster moves closer to first pitch at 9:40 PM ET.

Seattle Mariners Preview & Probable Pitcher

The Seattle Mariners sit at 73-83 hosting from T-Mobile Park. Probable starter: Logan Gilbert (12-10, 3.69).

How to watch: MLB.TV / Space City Home Network / Mariners.TV. Odds and totals can shift through the afternoon and evening — recheck your book for the latest Houston Astros vs Seattle Mariners line before the September 22, 2026 first pitch.

Where to Watch Houston Astros vs Seattle Mariners

Tune in Tuesday, September 22, 2026 at 9:40 PM ET from T-Mobile Park. Broadcast coverage: MLB.TV / Space City Home Network / Mariners.TV.