Our Titans vs Colts preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 6 matchup between the Tennessee Titans (0-5) and the Indianapolis Colts (2-3) on Sunday, October 18, 2026, at Lucas Oil Stadium in Indianapolis, IN. Kickoff is 1:00 PM ET (10:00 AM PT), and the game airs on FOX.
Week 6 storyline: Winless Tennessee visits Indianapolis after a 26-3 home loss to Houston. Robert Saleh said afterward that Cam Ward remains his starter, and ESPN noted the Titans have lost 11 straight division games. The Colts lost 34-22 at Pittsburgh as their defense struggled again (ESPN).
As of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), DraftKings via ESPN lists the Colts as 7-point favorites over the Titans, with the moneyline at Titans +270 / Colts -340 and the over/under at 44.5. Since the open, the spread has moved from IND -3.5 to IND -7 and the total has moved from 48.5 to 44.5. Below are the full Titans vs Colts odds, both team previews, the latest Week 6 injury news and TV details.
Titans vs Colts Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Tennessee Titans at Indianapolis Colts |
| Records | Titans 0-5 (0-2 road) · Colts 2-3 (1-1 home) |
| Spread | Titans +7 (-112) · Colts -7 (-108) |
| Moneyline | Titans +270 · Colts -340 |
| Total | 44.5 (Over -102 / Under -118) |
| Venue | Lucas Oil Stadium, Indianapolis, IN |
| Date/Time | Sunday, October 18, 2026 · 1:00 PM ET (10:00 AM PT) |
| TV | FOX |
| Head Coaches | Titans: Robert Saleh · Colts: Shane Steichen |
| Starting QBs | Titans: Cam Ward · Colts: Daniel Jones |
Odds: DraftKings via ESPN as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET). Opening line: IND -3.5, total 48.5, moneyline Titans +160 / Colts -192. Line movement: the spread has moved from IND -3.5 to IND -7, the total has moved from 48.5 to 44.5, and the moneyline has gone from Titans +160 / Colts -192 at the open to Titans +270 / Colts -340. Spread and total prices are shown in parentheses. Lines can move before kickoff.
Tennessee Titans Preview
2026 results through Week 6: Week 1: vs Jets, L 10-23 · Week 2: vs Eagles, L 20-24 · Week 3: at Giants, L 7-12 · Week 4: at Ravens, L 18-24 · Week 5: vs Texans, L 3-26. Points: 58 scored, 109 allowed.
Season so far: Tennessee lost 23-10 to the Jets, 24-20 to Philadelphia, 12-7 at the Giants, 24-18 at Baltimore and 26-3 to Houston. The Titans have scored 58 points in five games.
Quarterback and key players: Ward is 98 of 155 for 896 yards with three touchdowns and three interceptions. Tony Pollard has 273 rushing yards, rookie WR Carnell Tate has 274 receiving yards, Jacob Martin has 2.5 sacks and Anthony Hill Jr. has 47 tackles (ESPN).
This week: S Amani Hooker (concussion) and TE David Martin-Robinson (hamstring) are listed out, CB Cor’Dale Flott (chest) and S Kevin Winston Jr. (quadriceps) are questionable, and CB Joshua Williams went on injured reserve.
Indianapolis Colts Preview
2026 results through Week 6: Week 1: vs Ravens, L 23-41 · Week 2: at Chiefs, L 30-33 · Week 3: vs Texans, W 19-17 · Week 4: at Commanders (London), W 30-13 · Week 5: at Steelers, L 22-34. Points: 124 scored, 138 allowed.
Season so far: Indianapolis lost 41-23 to Baltimore and 33-30 at Kansas City, beat Houston 19-17 and won 30-13 at Washington, then lost in Pittsburgh. The Colts have scored 124 points and allowed 138.
Quarterback and key players: Daniel Jones is 108 of 176 for 1,021 yards with three touchdowns and four interceptions. Jonathan Taylor has 398 rushing yards and six touchdowns, Josh Downs has 249 receiving yards, DeForest Buckner has four sacks and Akeem Davis-Gaither has 44 tackles (ESPN).
This week: DE Arden Key (hamstring) and TE Will Mallory (thumb) went on injured reserve, and WRs Darius Slayton (knee) and Ashton Dulin (hamstring) and LB Jaylon Carlies (ribs) are listed out.
Titans vs Colts Key Injuries
Source: ESPN’s injury tracker as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET), with team-site, ESPN and NFL Network reporting for context. These are tracker statuses after Week 6, not official game designations: official Week 6 reports for this game run Wednesday through Friday, with game designations on Friday, Oct. 16. Some players listed questionable left Week 6 games and have not been updated yet.
Tennessee Titans — Out: TE David Martin-Robinson (hamstring); S Amani Hooker (concussion) · Doubtful: none · Questionable: S Kevin Winston Jr. (quadriceps); CB Cor’Dale Flott (chest) · Recent injured reserve moves (ESPN): CB Joshua Williams (pectoral).
Indianapolis Colts — Out: WR Darius Slayton (knee); WR Ashton Dulin (hamstring); LB Jaylon Carlies (ribs) · Doubtful: none · Questionable: none · Recent injured reserve moves (ESPN): DE Arden Key (hamstring); TE Will Mallory (thumb).
Titans vs Colts Key Matchup Notes
- Division game: Both teams play in the AFC South. Tennessee is 0-5 and the Colts are 2-3.
- Taylor vs the Tennessee defense: Taylor has six rushing touchdowns; the Titans allowed 26 points to Houston.
- Tennessee’s scoring: The Titans have not scored more than 20 points in a game this season.
- Line movement: The spread opened at Colts -3.5; see the odds table for the current number.
- Market snapshot: DraftKings opened IND -3.5 with a 48.5 total and now shows IND -7 and 44.5 (DraftKings via ESPN, as of 1:59 AM PT Tuesday).
Kickoff, Venue & How to Watch Tennessee Titans vs Indianapolis Colts
- Date: Sunday, October 18, 2026
- Kickoff: 1:00 PM ET (10:00 AM PT)
- Venue: Lucas Oil Stadium, Indianapolis, IN
- TV / Streaming: FOX (regional broadcast; check local listings). Streaming: Fox One and the FOX Sports app (local FOX feed), NFL+ on phones and tablets, and NFL Sunday Ticket on YouTube / YouTube TV for out-of-market viewers
Where to watch: the Tennessee Titans vs Indianapolis Colts game airs on FOX at 1:00 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it is not gambling advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Tuesday, Oct. 13, 2026, 1:59 AM PT (4:59 AM ET) for the Titans vs Colts game on October 18, 2026.