The Louisville Cardinals (3-3) visit the Syracuse Orange (2-3) on Saturday, October 17, 2026 at JMA Wireless Dome, Syracuse, NY. Kickoff is scheduled for 7:30 PM ET, and the game airs on ACC Network. DraftKings lists the spread at LOU -13.5 with a total of 56.5; moneylines are Louisville -535 · Syracuse +400. Below is our Louisville vs Syracuse preview with the latest odds, point spread, moneyline, over/under, kickoff time, TV channel and where to watch, plus a look at each team’s season so far, head coach and key players. Lines may move before kickoff.
Louisville vs Syracuse Odds, Spread, Kickoff Time & TV
| Matchup detail | Line / info |
|---|---|
| Matchup | Louisville at Syracuse |
| Records | Louisville 3-3 · Syracuse 2-3 |
| Spread | LOU -13.5 |
| Moneyline | Louisville -535 · Syracuse +400 |
| Total | 56.5 |
| Venue | JMA Wireless Dome, Syracuse, NY |
| Date/Time | Saturday, October 17, 2026 · 7:30 PM ET |
| TV / How to Watch | ACC Network |
| Head Coaches | Louisville: HC Jeff Brohm, OC Brian Brohm · Syracuse: HC Fran Brown, OC Mike Johnson / Jeff Nixon |
Louisville Preview: Season So Far, Coach & Key Players
Season so far: The Louisville Cardinals are 3-3 overall, 2-2 in ACC play. Results to date: Sep 6 — L 41-38 at Ole Miss (neutral site); Sep 11 — W 59-13 vs Villanova; Sep 19 — W 41-31 vs SMU; Sep 26 — L 30-27 vs Wake Forest; Oct 3 — L 31-28 at NC State; Oct 9 — W 44-20 vs Florida State. Most recently, Louisville beat Florida State 44-20 at home. Through 6 games, Louisville is averaging 39.5 points scored and 27.7 points allowed per game.
Head coach: Jeff Brohm (head coach since 2023). Offensive coordinator: Brian Brohm. Defensive coordinators: Steve Ellis / Mark Ivey.
Key players (2026 season stats):
- Passing leader: Lincoln Kienholz (QB) — 107/154, 1,534 yards, 9 TD, 1 INT
- Rushing leader: Isaac Brown (RB) — 74 carries, 557 yards, 4 TD
- Receiving leader: Tre Richardson (WR) — 29 receptions, 445 yards, 2 TD
- Sacks leader: Clev Lubin (DL) — 4 sacks
- Tackles leader: T.J. Capers (LB) — 48 total tackles
Strengths: An offense scoring 39.5 points per game; Lincoln Kienholz’s passing volume (1,534 yards); Isaac Brown’s production on the ground (557 rushing yards). Questions: A defense allowing 27.7 points per game.
Syracuse Preview: Season So Far, Coach & Key Players
Season so far: The Syracuse Orange are 2-3 overall, 0-3 in ACC play. Results to date: Sep 5 — W 66-3 vs New Hampshire; Sep 12 — L 21-18 vs California; Sep 17 — L 27-13 at Pittsburgh; Oct 3 — W 42-41 at UConn; Oct 10 — L 28-25 at Virginia. Most recently, Syracuse lost to Virginia 28-25 on the road. Through 5 games, Syracuse is averaging 32.8 points scored and 24.0 points allowed per game.
Head coach: Fran Brown (head coach since 2024). Offensive coordinators: Mike Johnson / Jeff Nixon. Defensive coordinator: Vince Kehres.
Key players (2026 season stats):
- Passing leader: Steve Angeli (QB) — 57/104, 731 yards, 4 TD, 5 INT
- Rushing leader: Tylik Hill (RB) — 69 carries, 405 yards, 1 TD
- Receiving leader: Umari Hatcher (WR) — 37 receptions, 560 yards, 6 TD
- Sacks leader: Keyshawn Johnson (LB) — 4 sacks
- Tackles leader: Chris D'Appolonia (LB) — 30 total tackles
Strengths: An offense averaging 32.8 points per game; a pass rush paced by Keyshawn Johnson (4 sacks). Questions: Ball security at quarterback (5 interceptions for Steve Angeli); the response to a 28-25 loss at Virginia.
How to Watch Louisville vs Syracuse
- Date: Saturday, October 17, 2026
- Kickoff: 7:30 PM ET
- Venue: JMA Wireless Dome, Syracuse, NY
- TV / Streaming: ACC Network
Odds: DraftKings lines reported via ESPN as of October 12, 2026 2:12 AM PT (Arizona time). Lines may move before kickoff. Records, results and season stats via ESPN; coaching staffs per 2026 staff listings. This page is an informational matchup preview only.