Our Colts vs Steelers preview covers the latest odds, point spread, moneyline, total, kickoff time, TV channel and where to watch for the NFL Week 5 matchup between the Indianapolis Colts (2-2) and the Pittsburgh Steelers (2-2) on Sunday, October 11, 2026, at Acrisure Stadium in Pittsburgh, PA. Kickoff is 1:00 PM ET (10:00 AM PT), and the game airs on CBS.
Week 5 storyline: Indianapolis returns from London with a two-game winning streak after beating Washington 30-13 at Tottenham Hotspur Stadium, where Jonathan Taylor ran for two touchdowns. Pittsburgh is coming off a 27-24 Thursday night loss in Cleveland, giving the Steelers 10 days between games, and has won both of its home games (AP).
As of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET), DraftKings via ESPN lists the Steelers as 2.5-point favorites over the Colts, with the moneyline at Colts +114 / Steelers -135 and the over/under at 44.5. Since the open, the spread is unchanged from the open at PIT -2.5 and the total has moved from 47.5 to 44.5. Below are the full Colts vs Steelers odds, both team previews, the latest Week 5 injury news and TV details.
Colts vs Steelers Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Indianapolis Colts at Pittsburgh Steelers |
| Records | Colts 2-2 (1-1 road) · Steelers 2-2 (2-0 home) |
| Spread | Colts +2.5 (-110) · Steelers -2.5 (-110) |
| Moneyline | Colts +114 · Steelers -135 |
| Total | 44.5 (Over -108 / Under -112) |
| Venue | Acrisure Stadium, Pittsburgh, PA |
| Date/Time | Sunday, October 11, 2026 · 1:00 PM ET (10:00 AM PT) |
| TV | CBS |
| Head Coaches | Colts: Shane Steichen · Steelers: Mike McCarthy |
| Starting QBs | Colts: Daniel Jones · Steelers: Aaron Rodgers |
Odds: DraftKings via ESPN as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET). Opening line: PIT -2.5, total 47.5, moneyline Colts +114 / Steelers -135. Line movement: the spread is unchanged from the open at PIT -2.5, the total has moved from 47.5 to 44.5, and the moneyline is unchanged. Spread and total prices are shown in parentheses. Lines can move before kickoff.
Indianapolis Colts Preview
2026 results through Week 4: Week 1: vs Ravens, L 23-41 · Week 2: at Chiefs, L 30-33 · Week 3: vs Texans, W 19-17 · Week 4: at Commanders (London), W 30-13. Points: 102 scored, 104 allowed.
Season so far: Indianapolis lost 41-23 at home to Baltimore and 33-30 in overtime at Kansas City, ended a nine-game losing streak with a 19-17 win over Houston on Spencer Shrader’s field goal with 16 seconds left, and beat the Commanders 30-13 in London (AP).
Quarterback and key players: Daniel Jones is 84 of 132 for 754 yards with three touchdowns and four interceptions (ESPN), and he has lost three fumbles over the past two weeks. Taylor has 353 rushing yards and six touchdowns, Josh Downs leads with 17 catches for 202 yards, DeForest Buckner has three sacks and LB Akeem Davis-Gaither has 37 tackles.
This week: WR Keenan Allen (groin) is listed out again, DE Arden Key (hamstring) has been ruled out for Pittsburgh, per The Athletic, and WR Alec Pierce (heel) remains on injured reserve; Shane Steichen said Pierce did not need surgery. The Colts flew home after a 9:30 AM ET kickoff in London (ESPN).
Pittsburgh Steelers Preview
2026 results through Week 4: Week 1: vs Falcons, W 20-13 · Week 2: at Patriots, L 3-20 · Week 3: vs Bengals, W 30-27 · Week 4: at Browns, L 24-27. Points: 77 scored, 87 allowed.
Season so far: Pittsburgh beat Atlanta 20-13 on T.J. Watt’s late interception return for a touchdown, lost 20-3 at New England, edged Cincinnati 30-27 on a late Chris Boswell kick and fell 27-24 in Cleveland on Oct. 1 (AP).
Quarterback and key players: Aaron Rodgers, in his 22nd season, is 88 of 153 for 999 yards with seven touchdowns and four interceptions (ESPN); he threw for 299 yards and three scores in Cleveland. Jaylen Warren has 309 rushing yards, DK Metcalf has 16 catches for 213 yards, Watt has 4.5 sacks and LB Payton Wilson leads with 36 tackles.
This week: DT Derrick Harmon (foot) went on injured reserve Monday, CB Jamel Dean (ankle) is doubtful and could miss a couple of weeks, and Mike McCarthy said RB Rico Dowdle (toe) is making progress, but his Week 5 availability is uncertain. Pittsburgh traded CB Joey Porter Jr. to Dallas last week (ESPN, NFL Network, PennLive).
Colts vs Steelers Key Injuries
Source: ESPN’s injury tracker as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET), with team-site, ESPN and NFL Network reporting for context. These are tracker statuses after Week 4, not official game designations: official Week 5 reports for this game run Wednesday through Friday, with game designations on Friday, Oct. 9. Some players listed questionable left Week 4 games and have not been updated yet.
Indianapolis Colts — Out: DE Arden Key (hamstring); WR Keenan Allen (groin) · Doubtful: none · Questionable: none · Recent injured reserve moves (ESPN): WR Alec Pierce (heel); DE Micheal Clemons (toe).
Pittsburgh Steelers — Out: RB Rico Dowdle (toe) · Doubtful: CB Jamel Dean (ankle) · Questionable: none · Recent injured reserve moves (ESPN): DT Derrick Harmon (foot).
Context: Pittsburgh has had 10 days since its Thursday game, while Indianapolis is coming off international travel. McCarthy said he regretted a heated sideline exchange with Rodgers in Cleveland (ESPN).
Colts vs Steelers Key Matchup Notes
- Taylor vs the Pittsburgh front: Taylor has six rushing touchdowns, including two in London, and the Steelers are without Harmon.
- Watt vs the Colts’ line: Watt has 4.5 sacks; Indianapolis will be without Key on its own pass rush.
- Ball security: Jones has four interceptions this season and has lost three fumbles over the past two weeks; Rodgers has four interceptions.
- Home and road: Pittsburgh is 2-0 at Acrisure Stadium and 0-2 on the road. The Colts are 1-1 away from home.
- Market snapshot: DraftKings opened PIT -2.5 with a 47.5 total and now shows PIT -2.5 and 44.5 (DraftKings via ESPN, as of 2:18 AM PT Tuesday).
Kickoff, Venue & How to Watch Indianapolis Colts vs Pittsburgh Steelers
- Date: Sunday, October 11, 2026
- Kickoff: 1:00 PM ET (10:00 AM PT)
- Venue: Acrisure Stadium, Pittsburgh, PA
- TV / Streaming: CBS (regional broadcast; check local listings). Streaming: Paramount+ carries the local CBS feed, NFL+ streams local games on phones and tablets, and out-of-market viewers can use NFL Sunday Ticket on YouTube / YouTube TV
Where to watch: the Indianapolis Colts vs Pittsburgh Steelers game airs on CBS at 1:00 PM ET. Final inactives are released about 90 minutes before kickoff.
This preview is for informational purposes only. It reports odds, injury designations and broadcast details from DraftKings via ESPN, NFL.com, team sites, ESPN and AP, and it is not gambling advice. Odds, injury statuses and inactives can change before kickoff, so confirm with official sources. If you gamble, do so legally and responsibly; help is available at 1-800-GAMBLER. Information current as of Tuesday, Oct. 6, 2026, 2:18 AM PT (5:18 AM ET) for the Colts vs Steelers game on October 11, 2026.