Our San Diego Padres vs Milwaukee Brewers preview covers the odds, run line, total, probable pitchers, first pitch time, TV channel and where to watch for Game 2 of the National League Division Series (NLDS) on Sunday, October 4, 2026. The No. 4-seeded San Diego Padres (91-71) and the No. 1-seeded Milwaukee Brewers (103-59) meet again at American Family Field in Milwaukee, Wis., in the best-of-five series, which the Brewers lead 1-0. First pitch is 4:00 PM ET (3:00 PM CT). TV: FS1 / FOX One.
Division Series storyline: Milwaukee won Game 1 3-2 on Saturday night on William Contreras’ tiebreaking homer in the seventh after Jackson Chourio’s two-run homer tied it in the third. San Diego reached the NLDS by sweeping the Cubs at Petco Park, allowing one run in two Wild Card games. Milwaukee went 103-59, the best record in the majors, and had a first-round bye. San Diego won the regular-season series 4-2. The probable pitchers are Michael King for the Padres and Logan Henderson for the Brewers. DraftKings lists the Brewers at -149 on the moneyline and the Padres at +123, with the total at 7.
San Diego Padres vs Milwaukee Brewers Odds, Run Line & Game Info
| Matchup | San Diego Padres @ Milwaukee Brewers |
|---|---|
| Series | National League Division Series (NLDS), Game 2 — best-of-five, 2-2-1 format |
| Series Score | Brewers lead 1-0 (Brewers won Game 1 3-2 on Oct. 3). Game 3: Tuesday, Oct. 6, 9:30 PM ET at Petco Park; Game 4 (if necessary): Wednesday, Oct. 7, 10 PM ET at Petco Park; Game 5 (if necessary): Friday, Oct. 9, 4:30 PM ET at American Family Field |
| Seeds | San Diego Padres No. 4 | Milwaukee Brewers No. 1 (NL) |
| 2026 Records | San Diego Padres 91-71 (40-41 on the road) | Milwaukee Brewers 103-59 (55-26 at home) |
| How They Got Here | Padres: Swept the No. 5 Chicago Cubs 2-0 in the NL Wild Card Series (8-0, 4-1) | Brewers: First-round bye as NL Central champion and No. 1 seed |
| Run Line | Padres +1.5 (-187) | Brewers -1.5 (+154) |
| Moneyline | San Diego Padres: +123 | Milwaukee Brewers: -149 |
| Total | O/U 7 (Over -111 / Under -109) |
| Probable Pitchers | Padres: Michael King (RHP, 12-10, 3.21 ERA, 32 GS, 185.0 IP, 159 K, 70 BB, 1.18 WHIP) | Brewers: Logan Henderson (RHP, 11-3, 2.47 ERA, 18 GS, 98.1 IP, 110 K, 19 BB, 0.84 WHIP) |
| Managers | San Diego Padres: Craig Stammen | Milwaukee Brewers: Pat Murphy |
| Venue | American Family Field (Milwaukee, Wis.) |
| Date / Time | Sunday, October 4, 2026 — 4:00 PM ET (3:00 PM CT) |
| TV / How to Watch | FS1 / FOX One |
| 2026 Season Series | Padres won the 2026 season series 4-2 |
Odds via DraftKings (through ESPN) as of Sunday, Oct. 4, 2026, 1:26 AM ET. Opening line: Padres +109 / Brewers -131, total 7. Lines move, so check your sportsbook before first pitch.
Padres vs Brewers NLDS Series Context
Format: The NLDS is a best-of-five series in a 2-2-1 format. Games 1 and 2 are at American Family Field, Games 3 and 4 move to Petco Park in San Diego, and a deciding Game 5 would return to Milwaukee. Remaining schedule (times ET): Game 3: Tuesday, Oct. 6, 9:30 PM ET at Petco Park; Game 4 (if necessary): Wednesday, Oct. 7, 10 PM ET at Petco Park; Game 5 (if necessary): Friday, Oct. 9, 4:30 PM ET at American Family Field (MLB Stats API).
Game 1 recap: William Contreras hit a tiebreaking solo homer off Adrian Morejon (L) with two outs in the seventh inning, and the Brewers beat the Padres 3-2 at American Family Field on Saturday night. San Diego scored twice in the second on RBIs from Luis Campusano and Jake Cronenworth, and Jackson Chourio tied it in the third with a two-run homer off Robbie Ray, giving the 22-year-old a franchise-record five career postseason homers (MLB.com). Ray lasted 2 2/3 innings (4 H, 2 R, 2 BB, 45 pitches), and Jacob Misiorowski went four innings (4 H, 2 R, 1 BB, 6 K, 88 pitches). DL Hall (W) escaped a bases-loaded jam in the seventh, and Trevor Megill got the final four outs for the save, striking out Fernando Tatis Jr. with the tying run on third in the eighth. In the ninth, Ty France’s deep drive hit a roof cable and was caught by Chourio, and the out stood after a replay review (MLB.com). San Diego outhit Milwaukee 9-7 but went 1-for-9 with runners in scoring position and left 12 on base (MLB Stats API box score).
How they got here: San Diego swept the Cubs in the Wild Card Series, 8-0 behind seven one-hit innings from Michael King and 4-1 behind Gavin Sheets’ two-run homer and four scoreless innings from the bullpen. Milwaukee finished an MLB-best 103-59, won the NL Central and went 8-2 in its last 10 regular-season games (MLB Stats API).
Head-to-head: San Diego went 4-2 against Milwaukee in 2026. The Brewers won two of three at American Family Field in May (6-4 and 7-1), and the Padres swept three at Petco Park on Aug. 10-12, including a 3-2 win over Henderson (MLB Stats API).
San Diego Padres Preview: NLDS Game 2
Season in review: Under manager Craig Stammen, the Padres went 91-71, finished second in the NL West and earned the NL’s No. 4 seed. They were 51-30 at home and 40-41 on the road. San Diego scored 722 runs and allowed 681, hit .244 with a .717 OPS, stole 164 bases and posted a 3.99 team ERA with 48 saves (MLB Stats API).
Key players: Manny Machado led the club with 30 homers and 91 RBIs. Fernando Tatis Jr. hit .289 with an .828 OPS, 25 homers and 38 steals, and Jackson Merrill added 26 homers. Closer Mason Miller had 38 saves with a 1.67 ERA, and MLB.com describes Adrian Morejon as his primary setup man, with Bradgley Rodriguez, Jason Adam and Yuki Matsui available earlier in games.
Roster and injuries: Walker Buehler opened the series on the postseason paternity list, which allows him to be away for one to three days; right-hander Randy Vásquez fills his roster spot until he returns (MLB press release, MLB.com). Joe Musgrove, back from Tommy John surgery, remains on the roster (ESPN/AP). ESPN lists RHP Jeremiah Estrada (shoulder, 15-day IL), RHP Casey Mize (ankle, 15-day IL) and RHP Lucas Giolito (elbow, 60-day IL).
Milwaukee Brewers Preview: NLDS Game 2
Season in review: Manager Pat Murphy‘s Brewers went 103-59, including 55-26 at home and 48-33 on the road. Milwaukee scored 832 runs and allowed 618, hit .258 with a .744 OPS and a .341 on-base percentage, stole 162 bases and posted a 3.51 team ERA with 55 saves (MLB Stats API). MLB.com noted the Brewers ranked fifth in the majors with a 3.61 starters’ ERA.
Key players: Jake Bauers led the club with 26 homers and an .873 OPS. Jackson Chourio hit .291 with 25 homers and 23 steals, Brice Turang drove in 100 runs and William Contreras drove in 94. Trevor Megill had 30 saves (MLB Stats API team leaders).
Roster and injuries: Milwaukee carries 13 pitchers, including Dustin May and Kyle Harrison. 3B Joey Ortiz made the roster after missing the last two regular-season games with knee and abdominal issues, while C Bo Naylor, UT Brandon Lockridge and RHP Grant Anderson were left off (ESPN/AP). ESPN also lists RHPs Brandon Woodruff and Quinn Priester (shoulder, 60-day IL) and relievers Angel Zerpa and Brian Fitzpatrick (elbow, 60-day IL).
Starting Pitchers: Michael King vs Logan Henderson
Padres: Michael King (RHP). King went 12-10 with a 3.21 ERA in 32 starts, with 159 strikeouts, 70 walks, a 1.18 WHIP and a .221 opponents’ average in 185 innings, and he did not miss a start (MLB Stats API, Sportsnet). In Game 1 of the Wild Card Series on Sept. 29 he threw seven scoreless innings against the Cubs, allowing one hit with eight strikeouts on 97 pitches, and MLB.com noted he carried a no-hitter into the seventh. MLB.com lists his career postseason ERA at 2.05. He starts on regular rest, which would also line him up for a potential Game 5 on Friday (San Diego Union-Tribune via FantasyPros, NBC Sports). He faced Milwaukee once this season, allowing one earned run in 5 2/3 innings on May 13 in a 3-1 San Diego win (MLB Stats API).
Brewers: Logan Henderson (RHP). The 24-year-old went 11-3 with a 2.47 ERA in 18 starts, with 110 strikeouts, 19 walks, a 0.84 WHIP and a .183 opponents’ average in 98 1/3 innings (MLB Stats API). He spent May 26 to July 9 on the injured list with a low back strain (MLB.com, CBS Sports). MLB.com reported he has never allowed more than three runs in any of his 23 career starts, tying Zac Gallen for the longest such streak to begin a career since 1893. This is his postseason debut; he missed last October’s run while recovering from a forearm injury (MLB.com). He took the loss against San Diego on Aug. 10, allowing three runs in 6 1/3 innings with seven strikeouts, and his last start was Sept. 23 at Philadelphia (5 IP, 1 ER) (MLB Stats API).
Key Matchup Notes: Padres vs Brewers Game 2
- Right-handed starters: MLB.com noted Milwaukee was the top offense in baseball against right-handed pitching by wRC+ this season and ranked 13th against left-handers. King and Henderson are both right-handed.
- Control: Henderson walked 19 batters in 98 1/3 innings. King walked 70 in 185 innings (MLB Stats API).
- Bullpens: Miller (38 saves) and Megill (30 saves) close for their clubs. In Game 1, San Diego’s relievers covered 5 1/3 innings after Ray (Rodriguez 19 pitches, Matsui 15, Adam 16, Morejon 31), and Milwaukee’s covered five after Misiorowski (Senzatela 11, Ashby 23, Uribe 16, Hall 20, Megill 17) (MLB Stats API).
- Speed: The Padres stole 164 bases during the season and the Brewers stole 162 (MLB Stats API).
- Rotation plans: MLB.com reported Nick Pivetta is in line to start Game 3 for San Diego, while Milwaukee’s Game 3 starter is TBA, with May, Robert Gasser, Shane Drohan and Harrison among the options.
How to Watch San Diego Padres vs Milwaukee Brewers – NLDS Game 2
Date: Sunday, October 4, 2026
First pitch: 4:00 PM ET (3:00 PM CT)
Venue: American Family Field, Milwaukee, Wis.
TV / Streaming: FS1 and FOX One, with Spanish-language coverage on FOX Deportes (MLB Stats API, ESPN).
The series winner advances to the NLCS against the winner of the Braves-Dodgers NLDS. Game 3 is Tuesday, Oct. 6 at Petco Park, where MLB.com reported Nick Pivetta is in line to start for San Diego and listed Milwaukee’s starter as TBA, with a bullpen game possible. Check the run line, moneyline and total above against your sportsbook before the October 4, 2026 first pitch, and look for official lineups closer to game time.