Chicago Cubs Preview & Probable Pitcher

The Chicago Cubs enter Friday at 88-71 and travel to face the Boston Red Sox at Fenway Park. Slated starter: Clay Holmes (6-8, 3.25).

Track the run line, moneyline, and total listed above for this Game 1 odds preview. Double-check probable pitchers and any late roster moves closer to first pitch at 1:05 PM ET.

Boston Red Sox Preview & Probable Pitcher

The Boston Red Sox sit at 85-74 hosting from Fenway Park. Probable starter: TBD.

How to watch: MLB.TV / Marquee Sports Net. Odds and totals can shift through the afternoon and evening — recheck your book for the latest Chicago Cubs vs Boston Red Sox Game 1 line before the September 25, 2026 first pitch.

Where to Watch Chicago Cubs vs Boston Red Sox Game 1

Tune in Friday, September 25, 2026 at 1:05 PM ET from Fenway Park for doubleheader Game 1. Broadcast coverage: MLB.TV / Marquee Sports Net.