The Arizona Cardinals (1-1) face the San Francisco 49ers (2-0) on Sunday, September 27, 2026 at Levi's Stadium, Santa Clara, CA. Kickoff is scheduled for 4:05 PM ET. The game airs on FOX.
Below is a factual NFL Week 3 matchup preview with current odds information, including point spread, moneyline, over/under, venue, kickoff time, and TV. This is an informational odds and broadcast preview only — no free picks or betting advice. Lines may move before kickoff.
Cardinals vs 49ers Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Arizona Cardinals at San Francisco 49ers |
| Records | Cardinals 1-1 · 49ers 2-0 |
| Spread | SF -8.5 |
| Moneyline | Cardinals +350 · 49ers -455 |
| Total | 47.5 |
| Venue | Levi's Stadium, Santa Clara, CA |
| Date/Time | Sunday, September 27, 2026 · 4:05 PM ET |
| TV | FOX |
Odds: DraftKings lines reported via ESPN around research time. Lines may move before kickoff. This page is a matchup preview only and does not include free picks or betting recommendations.
Arizona Cardinals Preview
The Arizona Cardinals enter this Week 3 road matchup at 1-1 and travel to face the San Francisco 49ers at Levi’s Stadium, Santa Clara, CA. Kickoff is set for 4:05 PM ET on FOX. Public odds boards list the Cardinals at +350 on the moneyline with the posted SF -8.5 line. The consensus total sits near 47.5. This page is an odds, spread, kickoff, and TV preview only — recheck lines and availability closer to Sunday, September 27, 2026.
San Francisco 49ers Preview
The San Francisco 49ers host Week 3 action at Levi’s Stadium, Santa Clara, CA at 2-0. Broadcast coverage is on FOX at 4:05 PM ET. Use the table above for the latest listed spread (SF -8.5), moneyline (Cardinals +350 · 49ers -455), and total (47.5), and confirm where to watch in your market before kickoff.
Where to Watch
- Date: Sunday, September 27, 2026
- Time: 4:05 PM ET
- Venue: Levi’s Stadium, Santa Clara, CA
- TV: FOX
Mark your calendar for Sunday, September 27, 2026 at 4:05 PM ET. The Arizona Cardinals vs San Francisco 49ers Week 3 game is scheduled from Levi’s Stadium, Santa Clara, CA and airs on FOX. Odds can shift through the week — refresh your book for the current point spread, moneyline, and over/under before the ball is kicked.