The Los Angeles Chargers (0-2) face the Buffalo Bills (2-0) on Sunday, September 27, 2026 at Highmark Stadium, Orchard Park, NY. Kickoff is scheduled for 1:00 PM ET. The game airs on FOX.
Below is a factual NFL Week 3 matchup preview with current odds information, including point spread, moneyline, over/under, venue, kickoff time, and TV. This is an informational odds and broadcast preview only — no free picks or betting advice. Lines may move before kickoff.
Chargers vs Bills Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Los Angeles Chargers at Buffalo Bills |
| Records | Chargers 0-2 · Bills 2-0 |
| Spread | BUF -7 |
| Moneyline | Chargers +270 · Bills -340 |
| Total | 50.5 |
| Venue | Highmark Stadium, Orchard Park, NY |
| Date/Time | Sunday, September 27, 2026 · 1:00 PM ET |
| TV | FOX |
Odds: DraftKings lines reported via ESPN around research time. Lines may move before kickoff. This page is a matchup preview only and does not include free picks or betting recommendations.
Los Angeles Chargers Preview
The Los Angeles Chargers enter this Week 3 road matchup at 0-2 and travel to face the Buffalo Bills at Highmark Stadium, Orchard Park, NY. Kickoff is set for 1:00 PM ET on FOX. Public odds boards list the Chargers at +270 on the moneyline with the posted BUF -7 line. The consensus total sits near 50.5. This page is an odds, spread, kickoff, and TV preview only — recheck lines and availability closer to Sunday, September 27, 2026.
Buffalo Bills Preview
The Buffalo Bills host Week 3 action at Highmark Stadium, Orchard Park, NY at 2-0. Broadcast coverage is on FOX at 1:00 PM ET. Use the table above for the latest listed spread (BUF -7), moneyline (Chargers +270 · Bills -340), and total (50.5), and confirm where to watch in your market before kickoff.
Where to Watch
- Date: Sunday, September 27, 2026
- Time: 1:00 PM ET
- Venue: Highmark Stadium, Orchard Park, NY
- TV: FOX
Mark your calendar for Sunday, September 27, 2026 at 1:00 PM ET. The Los Angeles Chargers vs Buffalo Bills Week 3 game is scheduled from Highmark Stadium, Orchard Park, NY and airs on FOX. Odds can shift through the week — refresh your book for the current point spread, moneyline, and over/under before the ball is kicked.