The St. Louis Cardinals (76-80) visit the Pittsburgh Pirates (79-77) on Tuesday, September 22, 2026 at PNC Park. First pitch is set for 6:40 PM ET. TV: MLB.TV / Cardinals.TV.
St. Louis Cardinals vs Pittsburgh Pirates Odds & Preview Info
| Matchup | St. Louis Cardinals @ Pittsburgh Pirates |
|---|---|
| Records | St. Louis Cardinals 76-80 | Pittsburgh Pirates 79-77 |
| Run Line | STL +1.5 | PIT -1.5 |
| Moneyline | St. Louis Cardinals: +129 | Pittsburgh Pirates: -155 |
| Total | 7 |
| Venue | PNC Park |
| Date / Time | Tuesday, September 22, 2026 — 6:40 PM ET |
| TV / How to Watch | MLB.TV / Cardinals.TV |
| Probable Pitchers | St. Louis Cardinals: Andre Pallante (12-7, 3.70) | Pittsburgh Pirates: Jared Jones (4-6, 4.17) |
Odds shown via public sportsbooks (lines move — verify before betting).
St. Louis Cardinals Preview & Probable Pitcher
The St. Louis Cardinals enter Tuesday at 76-80 and travel to face the Pittsburgh Pirates at PNC Park. Slated starter: Andre Pallante (12-7, 3.70).
Track the run line, moneyline, and total listed above for this odds preview. Double-check probable pitchers and any late roster moves closer to first pitch at 6:40 PM ET.
Pittsburgh Pirates Preview & Probable Pitcher
The Pittsburgh Pirates sit at 79-77 hosting from PNC Park. Probable starter: Jared Jones (4-6, 4.17).
How to watch: MLB.TV / Cardinals.TV. Odds and totals can shift through the afternoon and evening — recheck your book for the latest St. Louis Cardinals vs Pittsburgh Pirates line before the September 22, 2026 first pitch.
Where to Watch St. Louis Cardinals vs Pittsburgh Pirates
Tune in Tuesday, September 22, 2026 at 6:40 PM ET from PNC Park. Broadcast coverage: MLB.TV / Cardinals.TV.