Wake Forest (2-1) faces No. 16 Louisville (2-1) on Saturday, September 26, 2026 at L&N Federal Credit Union Stadium, Louisville, KY. Kickoff is scheduled for 12:00 PM ET. The game airs on ESPN. Below is a factual Week 4 college football matchup preview with current odds where available — point spread, moneyline, over/under, venue, broadcast, and coaching staff. Lines may move before kickoff.
Wake Forest vs Louisville Odds & Preview Info
| Matchup detail | Line / info |
|---|---|
| Matchup | Wake Forest at No. 16 Louisville |
| Records | Wake Forest 2-1 · Louisville 2-1 |
| Spread | LOU -12.5 |
| Moneyline | Wake Forest +380 · Louisville -500 |
| Total | 58.5 |
| Venue | L&N Federal Credit Union Stadium, Louisville, KY |
| Date/Time | Saturday, September 26, 2026 · 12:00 PM ET |
| TV / How to Watch | ESPN |
| Head Coaches | Wake Forest: HC Jake Dickert, OC Rob Ezell · Louisville: HC Jeff Brohm, OC Brian Brohm |
Wake Forest Preview & Staff
Wake Forest (2-1) visits Louisville on Saturday, September 26, 2026. Wake Forest lists head coach Jake Dickert and offensive coordinator Rob Ezell. This Week 4 preview is informational only — no free picks or predictions. Early watch items include Week 4 identity, explosive-play balance, and matching the opponent's tempo in a ESPN window.
No. 16 Louisville Preview & Staff
No. 16 Louisville (2-1) hosts at L&N Federal Credit Union Stadium. Louisville lists head coach Jeff Brohm and offensive coordinator Brian Brohm. Home-field framing, early-season continuity, and situational football are the factual focus points for this Week 4 matchup preview.
Where to Watch
- Date: Saturday, September 26, 2026
- Time: 12:00 PM ET
- Venue: L&N Federal Credit Union Stadium, Louisville, KY
- TV: ESPN
Odds: DraftKings lines reported via ESPN around research time. Lines may move before kickoff. This page is a matchup preview only and does not include free picks or betting recommendations.