The Detroit Lions (1-0) face the Buffalo Bills (1-0) on Thursday, September 17, 2026 at Highmark Stadium, Orchard Park, NY. Kickoff is scheduled for 8:15 PM ET. The game airs on Prime Video. This Thursday Night Football Week 2 matchup is scheduled at Highmark Stadium.
Below is a factual NFL Week 2 matchup preview with current odds information, including point spread, moneyline, over/under, venue, kickoff time, and TV. This is an informational odds and broadcast preview only — no projected winner or betting advice. Lines may move before kickoff.
Lions vs Bills odds and betting lines
| Matchup detail | Line / info |
|---|---|
| Records | Lions 1-0 · Bills 1-0 |
| Point spread | DET +3.5 · BUF -3.5 |
| Moneyline | DET +154 · BUF -185 |
| Over/under | 53.5 |
| Location | Highmark Stadium, Orchard Park, NY |
| Date | Thursday, September 17, 2026 |
| Kickoff time | 8:15 PM ET |
| TV channel | Prime Video |
Odds shown via DraftKings@ESPN / public sportsbooks. Lines may move before kickoff — verify at your sportsbook. Some shops may show slight differences versus ESPN consensus.
How to watch Lions vs Bills
- Date: Thursday, September 17, 2026
- Time: 8:15 PM ET
- Venue: Highmark Stadium, Orchard Park, NY
- TV / where to watch: Prime Video
Detroit Lions preview
The Detroit Lions enter this Week 2 road matchup at 1-0 after Week 1. The Lions travel to face the Bills at Highmark Stadium with kickoff set for 8:15 PM ET on Prime Video. Public odds boards have the Lions listed at +154 on the moneyline against the posted BUF -3.5 home-favorite line. The consensus total sits near 53.5. This page is an odds, spread, kickoff, and TV preview only — recheck lines and availability closer to Thursday, September 17, 2026.
Buffalo Bills preview
The Buffalo Bills host Week 2 action at Highmark Stadium at 1-0 after Week 1. The Bills are listed as home favorites on the BUF -3.5 spread with a -185 moneyline. Broadcast coverage is on Prime Video at 8:15 PM ET. Use the table above for the latest listed spread, moneyline, and total, and confirm where to watch in your market before kickoff.
Lions vs Bills kickoff and TV info
Mark your calendar for Thursday, September 17, 2026 at 8:15 PM ET. The Detroit Lions vs Buffalo Bills Week 2 game is scheduled from Highmark Stadium, Orchard Park, NY and airs on Prime Video. Odds can shift through the week — refresh your book for the current point spread, moneyline, and over/under before the ball is kicked.