The Arizona Cardinals (ARI 0-0) face the Los Angeles Chargers (LAC 0-0) on Sunday, September 13, 2026 at SoFi Stadium, Inglewood. Kickoff is scheduled for 4:25 PM ET. The game airs on CBS. Los Angeles opens as a double-digit home favorite against Arizona on the late CBS window.
Below is a factual Week 1 NFL matchup preview with current DraftKings odds reported via FOX around Sept. 3, 2026, including point spread, moneyline, over/under, venue, and broadcast information. Lines may move before kickoff.
Cardinals vs Chargers odds and betting lines
| Matchup detail | Line / info |
|---|---|
| Records | Cardinals 0-0 · Chargers 0-0 |
| Point spread | ARI +10.5 · LAC -10.5 |
| Moneyline | ARI +410 · LAC -550 |
| Over/under | 46.5 |
| Location | SoFi Stadium, Inglewood |
| Date | Sunday, September 13, 2026 |
| Kickoff time | 4:25 PM ET |
| TV channel | CBS |
Odds are DraftKings lines reported via FOX around Sept. 3, 2026, and may move before kickoff.
How to watch Cardinals vs Chargers
- Date: Sunday, September 13, 2026
- Time: 4:25 PM ET
- Venue: SoFi Stadium, Inglewood
- TV: CBS
Arizona Cardinals preview
The Arizona Cardinals visit SoFi Stadium as double-digit underdogs (+10.5, +410 moneyline). Arizona enters at 0-0 with a 46.5 total for a 4:25 PM ET CBS kickoff. The large road spread and late-afternoon West Coast start frame the Cardinals’ Week 1 outlook.
Los Angeles Chargers preview
The Los Angeles Chargers host Arizona as 10.5-point favorites (-550 moneyline) at SoFi Stadium. Los Angeles is 0-0 entering one of Week 1’s largest listed spreads. Home-field role as a heavy favorite and the CBS late window outline the Chargers’ opener preview.