The San Francisco 49ers (SF 0-0) face the Los Angeles Rams (LAR 0-0) on Thursday, September 10, 2026 at Melbourne Cricket Ground, Melbourne, Australia. Kickoff is scheduled for 8:35 PM ET. The game airs on Netflix. This Week 1 matchup is widely framed as the first NFL regular-season game in Australia, airing on Netflix from Melbourne Cricket Ground.
Below is a factual Week 1 NFL matchup preview with current DraftKings odds reported via FOX around Sept. 3, 2026, including point spread, moneyline, over/under, venue, and broadcast information. Lines may move before kickoff.
49ers vs Rams odds and betting lines
| Matchup detail | Line / info |
|---|---|
| Records | 49ers 0-0 · Rams 0-0 |
| Point spread | SF +3.5 · LAR -3.5 |
| Moneyline | SF +164 · LAR -198 |
| Over/under | 48.5 |
| Location | Melbourne Cricket Ground, Melbourne, Australia |
| Date | Thursday, September 10, 2026 |
| Kickoff time | 8:35 PM ET |
| TV channel | Netflix |
Odds are DraftKings lines reported via FOX around Sept. 3, 2026, and may move before kickoff.
How to watch 49ers vs Rams
- Date: Thursday, September 10, 2026
- Time: 8:35 PM ET
- Venue: Melbourne Cricket Ground, Melbourne, Australia
- TV: Netflix
San Francisco 49ers preview
The San Francisco 49ers open Week 1 against NFC West rival Los Angeles in Melbourne, Australia. San Francisco enters at 0-0 and is listed as a +3.5 underdog (+164 moneyline) on DraftKings lines reported via FOX around Sept. 3. The historic first NFL Australia game, international travel, and a Thursday night Netflix window shape the 49ers’ Week 1 outlook.
Los Angeles Rams preview
The Los Angeles Rams are 3.5-point favorites (-198 moneyline) in the first NFL regular-season game staged in Australia. Los Angeles opens at 0-0 opposite San Francisco at Melbourne Cricket Ground, with an over/under of 48.5. Neutral-site/international venue factors, the Netflix broadcast, and the NFC West rivalry frame the Rams’ Week 1 preview.